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Brf2 BRF2, RNA polymerase III transcription initiation factor 50kDa subunit [ Mus musculus (house mouse) ]

Gene ID: 66653, updated on 11-Apr-2024

Summary

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Official Symbol
Brf2provided by MGI
Official Full Name
BRF2, RNA polymerase III transcription initiation factor 50kDa subunitprovided by MGI
Primary source
MGI:MGI:1913903
See related
Ensembl:ENSMUSG00000031487 AllianceGenome:MGI:1913903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BRFU; TFIIIB50; 2700059M06Rik; 5730512K07Rik
Summary
Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and TBP-class protein binding activity. Predicted to be involved in DNA-templated transcription, initiation; cellular response to oxidative stress; and regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human BRF2 (BRF2 RNA polymerase III transcription initiation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.3), ovary adult (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 15.91 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27613367..27618743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27123339..27128715, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4994 Neighboring gene STARR-seq mESC enhancer starr_21013 Neighboring gene pyridoxal phosphate binding protein Neighboring gene predicted gene, 39151 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene VISTA enhancer mm136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:28239113-28239296 Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene RAB11 family interacting protein 1 (class I) Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase III type 3 promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIB complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor IIIB 50 kDa subunit
Names
B-related factor 2
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025686.2 → NP_079962.1  transcription factor IIIB 50 kDa subunit

    See identical proteins and their annotated locations for NP_079962.1

    Status: VALIDATED

    Source sequence(s)
    AK012680
    Consensus CDS
    CCDS22211.1
    UniProtKB/Swiss-Prot
    Q3UAW9, Q9CZF0
    UniProtKB/TrEMBL
    A0A0R4J0C6
    Related
    ENSMUSP00000033877.5, ENSMUST00000033877.6
    Conserved Domains (2) summary
    COG1405
    Location:6 → 244
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    pfam08271
    Location:6 → 37
    TF_Zn_Ribbon; TFIIB zinc-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27613367..27618743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509180.4 → XP_006509243.1  transcription factor IIIB 50 kDa subunit isoform X1

    Conserved Domains (1) summary
    cl40454
    Location:1 → 28
    CYCLIN_SF; Cyclin box fold superfamily

  2. XM_036154240.1 → XP_036010133.1  transcription factor IIIB 50 kDa subunit isoform X1

    Conserved Domains (1) summary
    cl40454
    Location:1 → 28
    CYCLIN_SF; Cyclin box fold superfamily

  3. XM_006509181.4 → XP_006509244.1  transcription factor IIIB 50 kDa subunit isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UAW9.1 GenPept UniProtKB/Swiss-Prot:Q3UAW9

Gene LinkOut

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