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Tpgs2 tubulin polyglutamylase complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 66648, updated on 5-Mar-2024

Summary

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Official Symbol
Tpgs2provided by MGI
Official Full Name
tubulin polyglutamylase complex subunit 2provided by MGI
Primary source
MGI:MGI:1913898
See related
Ensembl:ENSMUSG00000024269 AllianceGenome:MGI:1913898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgs2; 5730437P09Rik; 5730494M16Rik
Summary
Predicted to be involved in protein polyglutamylation. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TPGS2 (tubulin polyglutamylase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 26.1), whole brain E14.5 (RPKM 7.5) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A2; 18 13.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (25260280..25301990, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (25127223..25168933, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr18:24835661-24835962 Neighboring gene molybdenum cofactor sulfurase Neighboring gene formin homology 2 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_44073 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_44075 Neighboring gene expressed sequence AW554918 Neighboring gene STARR-seq mESC enhancer starr_44077 Neighboring gene STARR-seq mESC enhancer starr_44078 Neighboring gene STARR-seq mESC enhancer starr_44080 Neighboring gene predicted gene, 32825 Neighboring gene CUGBP, Elav-like family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3225 Neighboring gene predicted gene 3227

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
  2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC91164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein polyglutamylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin polyglutamylase complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004361.2 → NP_001004361.2  tubulin polyglutamylase complex subunit 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC124441, AI666318, AK017728, BC060253, BQ770487
    Consensus CDS
    CCDS29105.2
    UniProtKB/Swiss-Prot
    Q66JT5, Q6PAK1
    UniProtKB/TrEMBL
    E9QLP0
    Related
    ENSMUSP00000111484.3, ENSMUST00000115817.3
    Conserved Domains (1) summary
    smart00860
    Location:43 → 192
    SMI1_KNR4; SMI1 / KNR4 family

  2. NM_001142697.1 → NP_001136169.1  tubulin polyglutamylase complex subunit 2 isoform b

    See identical proteins and their annotated locations for NP_001136169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC124441, AI666318, DV655125
    UniProtKB/Swiss-Prot
    Q66JT5, Q6PAK1
    Conserved Domains (1) summary
    smart00860
    Location:2 → 145
    SMI1_KNR4; SMI1 / KNR4 family

  3. NM_001142698.1 → NP_001136170.1  tubulin polyglutamylase complex subunit 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC124441, AK141632, BC060253, BQ770487
    Consensus CDS
    CCDS50240.1
    UniProtKB/TrEMBL
    E9PUD7
    Related
    ENSMUSP00000122538.2, ENSMUST00000148255.8
    Conserved Domains (1) summary
    smart00860
    Location:43 → 192
    SMI1_KNR4; SMI1 / KNR4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    25260280..25301990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526156.5 → XP_006526219.1  tubulin polyglutamylase complex subunit 2 isoform X1

RNA

  1. XR_003952537.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JT5.2 GenPept UniProtKB/Swiss-Prot:Q66JT5

Gene LinkOut

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