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Golph3 golgi phosphoprotein 3 [ Mus musculus (house mouse) ]

Gene ID: 66629, updated on 5-Mar-2024

Summary

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Official Symbol
Golph3provided by MGI
Official Full Name
golgi phosphoprotein 3provided by MGI
Primary source
MGI:MGI:1913879
See related
Ensembl:ENSMUSG00000022200 AllianceGenome:MGI:1913879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4733401N08Rik; 5730410D03Rik
Summary
Predicted to enable enzyme binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; cell adhesion molecule production; and cellular response to rapamycin. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in brain; embryo; limb; liver; and notochord. Orthologous to human GOLPH3 (golgi phosphoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 42.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 5.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (12319617..12351687)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (12320488..12351601)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12160369-12160618 Neighboring gene myotubularin related protein 12 Neighboring gene STARR-seq mESC enhancer starr_38019 Neighboring gene predicted gene, 46497 Neighboring gene predicted gene, 52210 Neighboring gene PDZ domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_38020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:12365796-12365983 Neighboring gene STARR-seq mESC enhancer starr_38025 Neighboring gene predicted gene, 52211 Neighboring gene STARR-seq mESC enhancer starr_38027 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury. Li T, et al. Mol Neurobiol, 2016 Mar. PMID 25633094
  2. Identification and characterization of a novel alternative splice variant of mouse GMx33alpha/GPP34. Nagano-Ito M, et al. Gene, 2007 Oct 1. PMID 17629635
  3. miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness. Zhang Q, et al. Theranostics, 2017. PMID 29187903, Free PMC Article
  4. A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Xie Z, et al. Dev Cell, 2018 Mar 26. PMID 29587143, Free PMC Article
  5. The identification of novel sequences expressed in the mouse notochord. Sowden JC, et al. Mamm Genome, 1997 Jan. PMID 9021147

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golph3 is a target gene of miR34a. miR34a/GOLPH3 axis abrogates cancer cell stemness involved in urothelial bladder cancer chemoresistance.
    Title: miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.
  2. The current study found that GOLPH3, an outer membrane protein of the Golgi complex, was significantly upregulated in N2A cells upon oxygen-glucose deprivation and reoxygenation.
    Title: GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi vesicle budding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi vesicle budding ISO
Inferred from Sequence Orthology
more info
  
involved_in asymmetric Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to rapamycin ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein retention in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Golgi phosphoprotein 3
Names
coat protein GPP34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025673.2 → NP_079949.1  Golgi phosphoprotein 3

    See identical proteins and their annotated locations for NP_079949.1

    Status: PROVISIONAL

    Source sequence(s)
    BC051035
    Consensus CDS
    CCDS27389.1
    UniProtKB/Swiss-Prot
    A6BLP3, Q99KY1, Q9CRA5, Q9D636
    Related
    ENSMUSP00000057375.6, ENSMUST00000059680.7
    Conserved Domains (1) summary
    pfam05719
    Location:62 → 271
    GPP34; Golgi phosphoprotein 3 (GPP34)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    12319617..12351687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520143.3 → XP_006520206.1  Golgi phosphoprotein 3 isoform X1

    Conserved Domains (1) summary
    pfam05719
    Location:60 → 227
    GPP34; Golgi phosphoprotein 3 (GPP34)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRA5.1 GenPept UniProtKB/Swiss-Prot:Q9CRA5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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