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Thg1l tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 66628, updated on 5-Mar-2024

Summary

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Official Symbol
Thg1lprovided by MGI
Official Full Name
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1913878
See related
Ensembl:ENSMUSG00000011254 AllianceGenome:MGI:1913878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; magnesium ion binding activity; and purine ribonucleoside triphosphate binding activity. Predicted to be involved in several processes, including protein homotetramerization; stress-induced mitochondrial fusion; and tRNA processing. Predicted to be located in mitochondrion. Predicted to be part of transferase complex. Human ortholog(s) of this gene implicated in autosomal recessive cerebellar ataxia. Orthologous to human THG1L (tRNA-histidine guanylyltransferase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.2), testis adult (RPKM 2.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.1; 11 27.47 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (45836132..45846330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (45945305..45955503, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene clathrin interactor 1 Neighboring gene STARR-seq mESC enhancer starr_29303 Neighboring gene STARR-positive B cell enhancer ABC_E5218 Neighboring gene U7 snRNP-specific Sm-like protein LSM11 Neighboring gene STARR-positive B cell enhancer ABC_E11765 Neighboring gene STARR-seq mESC enhancer starr_29307 Neighboring gene STARR-seq mESC enhancer starr_29308 Neighboring gene SRY (sex determining region Y)-box 30 Neighboring gene STARR-seq mESC enhancer starr_29309 Neighboring gene predicted gene 12165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107321, 1700121M19Rik, 5730409G07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA guanylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-induced mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of transferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable tRNA(His) guanylyltransferase
Names
interphase cyctoplasmic foci protein 45
NP_001074438.1
NP_001277666.1
XP_011247481.1
XP_030102090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080969.3 → NP_001074438.1  probable tRNA(His) guanylyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001074438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK010876, AL645948
    Consensus CDS
    CCDS36132.1
    UniProtKB/Swiss-Prot
    Q562D7, Q9CY52
    UniProtKB/TrEMBL
    Q8BT63
    Related
    ENSMUSP00000011398.7, ENSMUST00000011398.13
    Conserved Domains (1) summary
    COG4021
    Location:31 → 291
    Thg1; tRNA(His) 5'-end guanylyltransferase [Translation, ribosomal structure and biogenesis]

  2. NM_001290737.1 → NP_001277666.1  probable tRNA(His) guanylyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001277666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. This variant (2) has a shorter and distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AK016076, AL645948, BF469404
    Consensus CDS
    CCDS70167.1
    UniProtKB/TrEMBL
    Q9CQT0
    Related
    ENSMUSP00000104877.2, ENSMUST00000109254.2
    Conserved Domains (2) summary
    pfam14413
    Location:107 → 223
    Thg1C; Thg1 C terminal domain
    pfam04446
    Location:3 → 104
    Thg1; tRNAHis guanylyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    45836132..45846330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249179.3 → XP_011247481.1  probable tRNA(His) guanylyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011247481.1

    UniProtKB/TrEMBL
    Q9CQT0
    Conserved Domains (2) summary
    pfam14413
    Location:107 → 223
    Thg1C; Thg1 C terminal domain
    pfam04446
    Location:3 → 104
    Thg1; tRNAHis guanylyltransferase

  2. XM_030246230.2 → XP_030102090.1  probable tRNA(His) guanylyltransferase isoform X1

    UniProtKB/TrEMBL
    Q9CQT0
    Conserved Domains (2) summary
    pfam14413
    Location:107 → 223
    Thg1C; Thg1 C terminal domain
    pfam04446
    Location:3 → 104
    Thg1; tRNAHis guanylyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY52.1 GenPept UniProtKB/Swiss-Prot:Q9CY52

Gene LinkOut

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