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Ogfod2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 66627, updated on 5-Mar-2024

Summary

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Official Symbol
Ogfod2provided by MGI
Official Full Name
2-oxoglutarate and iron-dependent oxygenase domain containing 2provided by MGI
Primary source
MGI:MGI:1913877
See related
Ensembl:ENSMUSG00000023707 AllianceGenome:MGI:1913877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300006G11Rik; 5730405M13Rik
Summary
Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity. Is expressed in embryo. Orthologous to human OGFOD2 (2-oxoglutarate and iron dependent oxygenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 30.6), colon adult (RPKM 17.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ogfod2 in Genome Data Viewer
Location:
5 F; 5 63.39 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124250384..124253544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124112321..124115482)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124525186-124525369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124529132-124529326 Neighboring gene ATP-binding cassette, sub-family B member 9 Neighboring gene STARR-positive B cell enhancer ABC_E432 Neighboring gene predicted gene 16001 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 4 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2 Neighboring gene predicted gene, 52788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Modzelewski AJ, et al. Cell, 2021 Oct 28. PMID 34644528, Free PMC Article
  2. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
NP_001334407.1
NP_001348411.1
NP_001348412.1
NP_079947.1
XP_030110622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347478.3 → NP_001334407.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113474
    Consensus CDS
    CCDS84961.1
    UniProtKB/TrEMBL
    D3YU42
    Related
    ENSMUSP00000112701.2, ENSMUST00000119269.6

  2. NM_001361482.2 → NP_001348411.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113474
    Conserved Domains (1) summary
    smart00702
    Location:30 → 164
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  3. NM_001361483.2 → NP_001348412.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113474
    Conserved Domains (1) summary
    cl21496
    Location:122 → 234
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  4. NM_025671.4 → NP_079947.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_079947.1

    Status: VALIDATED

    Source sequence(s)
    AK018534, AU041636, BY126361
    Consensus CDS
    CCDS19672.1
    UniProtKB/Swiss-Prot
    Q78IV7, Q8BMW3, Q9CQ04
    Related
    ENSMUSP00000024470.7, ENSMUST00000024470.13
    Conserved Domains (1) summary
    smart00702
    Location:145 → 307
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124250384..124253544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254762.2 → XP_030110622.1  2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    smart00702
    Location:89 → 223
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ04.1 GenPept UniProtKB/Swiss-Prot:Q9CQ04

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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