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Cdip1 cell death inducing Trp53 target 1 [ Mus musculus (house mouse) ]

Gene ID: 66626, updated on 5-Mar-2024

Summary

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Official Symbol
Cdip1provided by MGI
Official Full Name
cell death inducing Trp53 target 1provided by MGI
Primary source
MGI:MGI:1913876
See related
Ensembl:ENSMUSG00000004071 AllianceGenome:MGI:1913876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDIP; 2700048O17Rik; 5730403B10Rik
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. Is expressed in embryo; otic pit; and otocyst. Orthologous to human CDIP1 (cell death inducing p53 target 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 59.3), testis adult (RPKM 47.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdip1 in Genome Data Viewer
Location:
16 A1; 16 2.47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4583325..4608156, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4765461..4790292, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene STARR-seq mESC enhancer starr_39942 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4726231-4726340 Neighboring gene NmrA-like family domain containing 1 Neighboring gene heme oxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_39943 Neighboring gene STARR-positive B cell enhancer ABC_E7425 Neighboring gene STARR-seq mESC enhancer starr_39945 Neighboring gene RIKEN cDNA 4930562C15 gene Neighboring gene predicted gene, 36513 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4878205-4878392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4879753-4879936 Neighboring gene UBA-like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Namba T, et al. Cell Rep, 2013 Oct 31. PMID 24139803, Free PMC Article
  2. A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p. Li M, et al. Theranostics, 2018. PMID 30613267, Free PMC Article
  3. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Liu J, et al. Cell Host Microbe, 2020 Sep 9. PMID 32544461, Free PMC Article
  4. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. Brown L, et al. EMBO J, 2007 Jul 25. PMID 17599062, Free PMC Article
  5. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
    Title: Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
  2. These findings reveal a novel regulatory pathway that comprises circular transcript of NCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis during ischemic cardiac disease.
    Title: A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p.
  3. CDIP1 Promotes Bax Oligomerization and Mitochondrial Translocation during endoplasmic reticulum Stress.
    Title: CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic side of late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell death-inducing p53-target protein 1
Names
LITAF-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358078.1 → NP_001345007.1  cell death-inducing p53-target protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC166903
    Consensus CDS
    CCDS27925.1
    UniProtKB/Swiss-Prot
    Q3UD73, Q9CYP1, Q9DB75
    Conserved Domains (1) summary
    pfam10601
    Location:137 → 205
    zf-LITAF-like; LITAF-like zinc ribbon domain

  2. NM_001358079.2 → NP_001345008.1  cell death-inducing p53-target protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC166903
    Conserved Domains (1) summary
    pfam10601
    Location:158 → 224
    zf-LITAF-like; LITAF-like zinc ribbon domain

  3. NM_001358080.2 → NP_001345009.1  cell death-inducing p53-target protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166903
    Conserved Domains (1) summary
    pfam10601
    Location:102 → 168
    zf-LITAF-like; LITAF-like zinc ribbon domain

  4. NM_001358081.2 → NP_001345010.1  cell death-inducing p53-target protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166903
    Consensus CDS
    CCDS88867.1
    Related
    ENSMUSP00000113618.2, ENSMUST00000117713.8
    Conserved Domains (1) summary
    pfam10601
    Location:120 → 186
    zf-LITAF-like; LITAF-like zinc ribbon domain

  5. NM_001358082.2 → NP_001345011.1  cell death-inducing p53-target protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166903
    Consensus CDS
    CCDS27925.1
    UniProtKB/Swiss-Prot
    Q3UD73, Q9CYP1, Q9DB75
    Related
    ENSMUSP00000113889.2, ENSMUST00000118703.8
    Conserved Domains (1) summary
    pfam10601
    Location:137 → 205
    zf-LITAF-like; LITAF-like zinc ribbon domain

  6. NM_025670.5 → NP_079946.2  cell death-inducing p53-target protein 1 isoform 4

    See identical proteins and their annotated locations for NP_079946.2

    Status: VALIDATED

    Source sequence(s)
    AC166903
    Consensus CDS
    CCDS27925.1
    UniProtKB/Swiss-Prot
    Q3UD73, Q9CYP1, Q9DB75
    Related
    ENSMUSP00000004173.6, ENSMUST00000004173.12
    Conserved Domains (1) summary
    pfam10601
    Location:137 → 205
    zf-LITAF-like; LITAF-like zinc ribbon domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4583325..4608156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249239.1 → XP_030105099.1  cell death-inducing p53-target protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UD73, Q9CYP1, Q9DB75
    Conserved Domains (1) summary
    pfam10601
    Location:137 → 205
    zf-LITAF-like; LITAF-like zinc ribbon domain

  2. XM_030249240.1 → XP_030105100.1  cell death-inducing p53-target protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UD73, Q9CYP1, Q9DB75
    Conserved Domains (1) summary
    pfam10601
    Location:137 → 205
    zf-LITAF-like; LITAF-like zinc ribbon domain

  3. XM_006522468.1 → XP_006522531.1  cell death-inducing p53-target protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006522531.1

    UniProtKB/Swiss-Prot
    Q3UD73, Q9CYP1, Q9DB75
    Conserved Domains (1) summary
    pfam10601
    Location:137 → 205
    zf-LITAF-like; LITAF-like zinc ribbon domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB75.1 GenPept UniProtKB/Swiss-Prot:Q9DB75

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