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Snx9 sorting nexin 9 [ Mus musculus (house mouse) ]

Gene ID: 66616, updated on 5-Mar-2024

Summary

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Official Symbol
Snx9provided by MGI
Official Full Name
sorting nexin 9provided by MGI
Primary source
MGI:MGI:1913866
See related
Ensembl:ENSMUSG00000002365 AllianceGenome:MGI:1913866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDP1; SH3PX1; 2700073N08Rik
Summary
Enables phosphatidylinositol binding activity. Involved in positive regulation of actin filament polymerization. Acts upstream of or within intracellular protein transport. Located in cytoplasm and plasma membrane. Colocalizes with cuticular plate. Is expressed in lower jaw molar and upper jaw molar. Orthologous to human SNX9 (sorting nexin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 37.0), large intestine adult (RPKM 23.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A1; 17 3.51 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (5891599..5982231)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (5841324..5931956)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3300005D01 gene Neighboring gene STARR-positive B cell enhancer ABC_E10931 Neighboring gene STARR-positive B cell enhancer ABC_E10932 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) pseudogene Neighboring gene predicted gene, 35474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:5885599-5885708 Neighboring gene STARR-positive B cell enhancer mm9_chr17:5934164-5934465 Neighboring gene STARR-positive B cell enhancer mm9_chr17:5934996-5935297 Neighboring gene STARR-seq mESC enhancer starr_41704 Neighboring gene predicted gene, 46599 Neighboring gene STARR-seq mESC enhancer starr_41705 Neighboring gene mRNA turnover 4 pseudogene Neighboring gene synaptojanin 2 Neighboring gene STARR-seq mESC enhancer starr_41707 Neighboring gene predicted gene, 52312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorting nexin 9 (SNX9) is not essential for development and auditory function in mice. Liu C, et al. Oncotarget, 2016 Oct 18. PMID 27655699, Free PMC Article
  2. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. MaCaulay SL, et al. Biochem J, 2003 Nov 15. PMID 12917015, Free PMC Article
  3. FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. Cao H, et al. PLoS One, 2013. PMID 23437151, Free PMC Article
  4. Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion. Schimenti JC, et al. Proc Natl Acad Sci U S A, 2005 Mar 1. PMID 15722415, Free PMC Article
  5. A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells. Nández R, et al. Elife, 2014 Aug 8. PMID 25107275, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid tube assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cuticular plate IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025664.6 → NP_079940.2  sorting nexin-9

    See identical proteins and their annotated locations for NP_079940.2

    Status: VALIDATED

    Source sequence(s)
    AC168063, AK155830
    Consensus CDS
    CCDS57041.1
    UniProtKB/Swiss-Prot
    Q91VH2
    UniProtKB/TrEMBL
    Q3TZU7, Q3U1P2
    Related
    ENSMUSP00000002436.10, ENSMUST00000002436.11
    Conserved Domains (3) summary
    cd07285
    Location:250 → 375
    PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
    cd07668
    Location:386 → 595
    BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
    cd11898
    Location:4 → 60
    SH3_SNX9; Src Homology 3 domain of Sorting nexin 9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    5891599..5982231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317612.3 → XP_017173101.1  sorting nexin-9 isoform X1

    UniProtKB/TrEMBL
    Q3TZU7
    Conserved Domains (4) summary
    cd07285
    Location:250 → 375
    PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
    cd07668
    Location:386 → 595
    BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
    cd11898
    Location:5 → 60
    SH3_SNX9; Src Homology 3 domain of Sorting nexin 9
    COG5391
    Location:127 → 357
    COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]

  2. XM_030249990.2 → XP_030105850.1  sorting nexin-9 isoform X2

    UniProtKB/TrEMBL
    Q9CZK0
    Conserved Domains (2) summary
    cd07285
    Location:50 → 175
    PX_SNX9; The phosphoinositide binding Phox Homology domain of Sorting Nexin 9
    cd07668
    Location:186 → 395
    BAR_SNX9; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VH2.1 GenPept UniProtKB/Swiss-Prot:Q91VH2

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