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Frmpd1 FERM and PDZ domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 666060, updated on 21-Apr-2024

Summary

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Official Symbol
Frmpd1provided by MGI
Official Full Name
FERM and PDZ domain containing 1provided by MGI
Primary source
MGI:MGI:2446274
See related
Ensembl:ENSMUSG00000035615 AllianceGenome:MGI:2446274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0967
Summary
Predicted to be involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell cortex. Orthologous to human FRMPD1 (FERM and PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 1.8), frontal lobe adult (RPKM 1.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 23.77 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45183958..45285936)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45184420..45285936)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene F-box protein 10 Neighboring gene predicted gene, 30939 Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45309913-45310096 Neighboring gene tRNA methyltransferase 10B Neighboring gene exosome component 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina. Campla CK, et al. eNeuro, 2022 Sep-Oct. PMID 36180221, Free PMC Article
  2. Structural and biochemical characterization of the interaction between LGN and Frmpd1. Pan Z, et al. J Mol Biol, 2013 Mar 25. PMID 23318951
  3. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina.
    Title: Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FERM and PDZ domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081172.3 → NP_001074641.1  FERM and PDZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_001074641.1

    Status: VALIDATED

    Source sequence(s)
    AL772285, AL824706
    Consensus CDS
    CCDS38753.1
    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0
    UniProtKB/TrEMBL
    B2RY18
    Related
    ENSMUSP00000047232.6, ENSMUST00000044773.12
    Conserved Domains (5) summary
    smart00295
    Location:182 → 401
    B41; Band 4.1 homologues
    cd00992
    Location:56 → 132
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:397 → 500
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd21942
    Location:901 → 938
    LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
    cl28922
    Location:179 → 268
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_001425126.1 → NP_001412055.1  FERM and PDZ domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AL772285, AL772322
    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0

  3. NM_001425127.1 → NP_001412056.1  FERM and PDZ domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AL772285, AL824706
    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45183958..45285936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538176.5 → XP_006538239.1  FERM and PDZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006538239.1

    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0
    UniProtKB/TrEMBL
    B2RY18
    Conserved Domains (5) summary
    smart00295
    Location:182 → 401
    B41; Band 4.1 homologues
    cd00992
    Location:56 → 132
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:397 → 500
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd21942
    Location:901 → 938
    LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
    cl28922
    Location:179 → 268
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006538178.4 → XP_006538241.1  FERM and PDZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006538241.1

    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0
    UniProtKB/TrEMBL
    B2RY18
    Conserved Domains (5) summary
    smart00295
    Location:182 → 401
    B41; Band 4.1 homologues
    cd00992
    Location:56 → 132
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:397 → 500
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd21942
    Location:901 → 938
    LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
    cl28922
    Location:179 → 268
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_006538175.4 → XP_006538238.1  FERM and PDZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006538238.1

    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0
    UniProtKB/TrEMBL
    B2RY18
    Conserved Domains (5) summary
    smart00295
    Location:182 → 401
    B41; Band 4.1 homologues
    cd00992
    Location:56 → 132
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:397 → 500
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd21942
    Location:901 → 938
    LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
    cl28922
    Location:179 → 268
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_011250085.4 → XP_011248387.1  FERM and PDZ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011248387.1

    UniProtKB/Swiss-Prot
    A2AKB4, Q80TN2, Q80XK5, Q8K0C0
    UniProtKB/TrEMBL
    B2RY18
    Conserved Domains (5) summary
    smart00295
    Location:182 → 401
    B41; Band 4.1 homologues
    cd00992
    Location:56 → 132
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:397 → 500
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd21942
    Location:901 → 938
    LGNbd_FRMPD1; LGN tetratricopeptide repeat-binding domain found in FERM and PDZ domain-containing protein 1
    cl28922
    Location:179 → 268
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AKB4.1 GenPept UniProtKB/Swiss-Prot:A2AKB4

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