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Trabd2b TraB domain containing 2B [ Mus musculus (house mouse) ]

Gene ID: 666048, updated on 11-Apr-2024

Summary

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Official Symbol
Trabd2bprovided by MGI
Official Full Name
TraB domain containing 2Bprovided by MGI
Primary source
MGI:MGI:3650152
See related
Ensembl:ENSMUSG00000070867 AllianceGenome:MGI:3650152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hkat; Gm12824
Summary
Predicted to enable Wnt-protein binding activity and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Predicted to be integral component of organelle membrane and integral component of plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; lung; and neural ectoderm. Orthologous to human TRABD2B (TraB domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 13.3), heart adult (RPKM 12.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Trabd2b in Genome Data Viewer
Location:
4 D1; 4 51.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114263394..114472295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (114406682..114615098)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 11 Neighboring gene TRAF3 interacting protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11102 Neighboring gene predicted gene, 40228 Neighboring gene predicted gene, 33710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114273999-114274108 Neighboring gene predicted gene, 33655 Neighboring gene predicted gene 12829 Neighboring gene RIKEN cDNA 9130410C08 gene Neighboring gene STARR-seq mESC enhancer starr_11104 Neighboring gene predicted gene 12830

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues. Zhang R. Sci Rep, 2012. PMID 23152936, Free PMC Article
  2. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. Reis AH, et al. Int J Dev Biol, 2014. PMID 25354456, Free PMC Article
  3. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. George MR, et al. Development, 2019 Dec 9. PMID 31784461, Free PMC Article
  4. Notum attenuates Wnt/β-catenin signaling to promote tracheal cartilage patterning. Gerhardt B, et al. Dev Biol, 2018 Apr 1. PMID 29428562, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hkat (Gm12824) is a novel nutritionally regulated gene that is potentially involved in metabolism.
    Title: Hkat, a novel nutritionally regulated transmembrane protein in adipose tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metalloprotease TIKI2
Names
TRAB domain-containing protein 2B
UPF0632 protein A
heart, kidney and adipose-enriched transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085549.1 → NP_001079018.1  metalloprotease TIKI2 precursor

    See identical proteins and their annotated locations for NP_001079018.1

    Status: PROVISIONAL

    Source sequence(s)
    AL646006, AL670175
    Consensus CDS
    CCDS38843.1
    UniProtKB/Swiss-Prot
    B1ATG9
    Related
    ENSMUSP00000092494.4, ENSMUST00000094894.4
    Conserved Domains (1) summary
    pfam01963
    Location:41 → 348
    TraB; TraB family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    114263394..114472295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503276.5 → XP_006503339.1  metalloprotease TIKI2 isoform X1

    Conserved Domains (1) summary
    cd14789
    Location:3 → 128
    Tiki; Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues

RNA

  1. XR_004941947.1 RNA Sequence

  2. XR_004941946.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1ATG9.1 GenPept UniProtKB/Swiss-Prot:B1ATG9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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