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Tmigd1 transmembrane and immunoglobulin domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66601, updated on 5-Mar-2024

Summary

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Official Symbol
Tmigd1provided by MGI
Official Full Name
transmembrane and immunoglobulin domain containing 1provided by MGI
Primary source
MGI:MGI:1913851
See related
Ensembl:ENSMUSG00000020839 AllianceGenome:MGI:1913851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmigd; 2010002A20Rik
Summary
Predicted to be involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of membrane permeability. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in neuron projection. Orthologous to human TMIGD1 (transmembrane and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 33.2) and kidney adult (RPKM 9.3) See more
Orthologs
human all
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Genomic context

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See Tmigd1 in Genome Data Viewer
Location:
11 B5; 11 46.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76781946..76807413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76891120..76916587)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30045 Neighboring gene carboxypeptidase D Neighboring gene predicted gene, 53688 Neighboring gene predicted gene, 40200 Neighboring gene STARR-seq mESC enhancer starr_30046 Neighboring gene STARR-positive B cell enhancer mm9_chr11:76759053-76759354 Neighboring gene STARR-seq mESC enhancer starr_30047 Neighboring gene bleomycin hydrolase Neighboring gene solute carrier family 6 member 4 gene promoter Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex. Hartmann C, et al. Sci Signal, 2022 Sep 13. PMID 36099341
  2. The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. Rahimi N, et al. J Biomed Sci, 2021 Sep 9. PMID 34503512, Free PMC Article
  3. TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells. Wu Y, et al. Oxid Med Cell Longev, 2021. PMID 34426761, Free PMC Article
  4. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. Arafa E, et al. Am J Pathol, 2015 Oct. PMID 26342724, Free PMC Article
  5. Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells. De La Cena KOC, et al. Am J Pathol, 2021 Jan. PMID 33129760, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223.
    Title: Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223.
  2. Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease.
    Title: Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn's disease.
  3. Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex.
    Title: Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex.
  4. TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells.
    Title: TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells.
  5. The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration.
    Title: The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration.
  6. Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
    Title: Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion mediator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cell-cell adhesion mediator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brush border assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell aggregation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell-cell junction organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to hydroperoxide IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intestinal epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intestinal epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cyclin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of membrane permeability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane and immunoglobulin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382246.1 → NP_001369175.1  transmembrane and immunoglobulin domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603842
    UniProtKB/TrEMBL
    Q9D8H2
    Conserved Domains (2) summary
    smart00410
    Location:163 → 244
    IG_like; Immunoglobulin like
    cd00096
    Location:171 → 175
    Ig; Ig strand B [structural motif]

  2. NM_001382247.1 → NP_001369176.1  transmembrane and immunoglobulin domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL603842
    UniProtKB/TrEMBL
    Q9D8H2
    Conserved Domains (2) summary
    smart00410
    Location:163 → 244
    IG_like; Immunoglobulin like
    cd00096
    Location:171 → 175
    Ig; Ig strand B [structural motif]

  3. NM_025655.3 → NP_079931.1  transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_079931.1

    Status: VALIDATED

    Source sequence(s)
    AL603842
    Consensus CDS
    CCDS25072.1
    UniProtKB/Swiss-Prot
    Q8R202, Q9D7L8
    UniProtKB/TrEMBL
    Q9D8H2
    Related
    ENSMUSP00000099553.2, ENSMUST00000102495.8
    Conserved Domains (1) summary
    smart00409
    Location:130 → 211
    IG; Immunoglobulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76781946..76807413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533950.3 → XP_006534013.1  transmembrane and immunoglobulin domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006534013.1

    UniProtKB/Swiss-Prot
    Q8R202, Q9D7L8
    UniProtKB/TrEMBL
    Q9D8H2
    Conserved Domains (1) summary
    smart00409
    Location:130 → 211
    IG; Immunoglobulin

  2. XM_036156900.1 → XP_036012793.1  transmembrane and immunoglobulin domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    Q9D8H2
    Conserved Domains (2) summary
    smart00410
    Location:163 → 244
    IG_like; Immunoglobulin like
    cd00096
    Location:171 → 175
    Ig; Ig strand B [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7L8.1 GenPept UniProtKB/Swiss-Prot:Q9D7L8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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