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Aste1 asteroid homolog 1 [ Mus musculus (house mouse) ]

Gene ID: 66595, updated on 5-Mar-2024

Summary

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Official Symbol
Aste1provided by MGI
Official Full Name
asteroid homolog 1provided by MGI
Primary source
MGI:MGI:1913845
See related
Ensembl:ENSMUSG00000032567 AllianceGenome:MGI:1913845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1100001A21Rik
Summary
Is expressed in brain. Orthologous to human ASTE1 (asteroid homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 4.8), limb E14.5 (RPKM 0.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 56.61 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (105272533..105285497)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105395294..105408299)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5099 Neighboring gene nudix hydrolase 16 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 11 Neighboring gene STARR-positive B cell enhancer ABC_E895 Neighboring gene STARR-positive B cell enhancer ABC_E3856 Neighboring gene STARR-positive B cell enhancer ABC_E5100 Neighboring gene ATPase, Ca++-sequestering Neighboring gene STARR-positive B cell enhancer mm9_chr9:105398187-105398487 Neighboring gene predicted gene, 40564 Neighboring gene STARR-seq mESC enhancer starr_25124 Neighboring gene STARR-seq mESC enhancer starr_25126 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection. Zhao F, et al. Nat Cell Biol, 2021 Aug. PMID 34354233
  2. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC107393

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein asteroid homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164828.1 → NP_001158300.1  protein asteroid homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001158300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC113016, AK006153
    Consensus CDS
    CCDS52905.1
    UniProtKB/TrEMBL
    E9Q1A4
    Related
    ENSMUSP00000131164.2, ENSMUST00000167674.2

  2. NM_001357902.1 → NP_001344831.1  protein asteroid homolog 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC113016, BC098471, CJ226565
    Consensus CDS
    CCDS90653.1
    Related
    ENSMUSP00000149596.2, ENSMUST00000123807.8

  3. NM_025651.5 → NP_079927.2  protein asteroid homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_079927.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC113016, AK030661
    Consensus CDS
    CCDS23465.1
    UniProtKB/Swiss-Prot
    Q4KMN1, Q80VC2, Q8BIR2
    Related
    ENSMUSP00000035181.4, ENSMUST00000035181.10
    Conserved Domains (1) summary
    cl28905
    Location:28 → 181
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RNA

  1. NR_152139.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113016

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    105272533..105285497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511784.5 → XP_006511847.1  protein asteroid homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006511847.1

    UniProtKB/Swiss-Prot
    Q4KMN1, Q80VC2, Q8BIR2
    Conserved Domains (1) summary
    cl28905
    Location:28 → 181
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  2. XM_030244494.1 → XP_030100354.1  protein asteroid homolog 1 isoform X4

    UniProtKB/TrEMBL
    Q9D1S8

  3. XM_030244493.2 → XP_030100353.1  protein asteroid homolog 1 isoform X2

    UniProtKB/TrEMBL
    Q9D1S8

  4. XM_006511787.4 → XP_006511850.1  protein asteroid homolog 1 isoform X3

    UniProtKB/TrEMBL
    Q9D1S8

  5. XM_006511789.5 → XP_006511852.1  protein asteroid homolog 1 isoform X4

    See identical proteins and their annotated locations for XP_006511852.1

    UniProtKB/TrEMBL
    Q9D1S8

RNA

  1. XR_871094.4 RNA Sequence

  2. XR_004935513.1 RNA Sequence

  3. XR_004935514.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIR2.1 GenPept UniProtKB/Swiss-Prot:Q8BIR2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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