U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stoml2 stomatin (Epb7.2)-like 2 [ Mus musculus (house mouse) ]

Gene ID: 66592, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Stoml2provided by MGI
Official Full Name
stomatin (Epb7.2)-like 2provided by MGI
Primary source
MGI:MGI:1913842
See related
Ensembl:ENSMUSG00000028455 AllianceGenome:MGI:1913842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSLP2; SLP-2; 0610038F01Rik
Summary
Predicted to enable GTPase binding activity and cardiolipin binding activity. Involved in several processes, including mitochondrial ATP synthesis coupled proton transport; positive regulation of interleukin-2 production; and stress-induced mitochondrial fusion. Located in mitochondrion. Is extrinsic component of plasma membrane. Orthologous to human STOML2 (stomatin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 48.2), CNS E11.5 (RPKM 43.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 A5; 4 22.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43027690..43031402, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43027690..43031976, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1029 Neighboring gene STARR-seq mESC enhancer starr_10044 Neighboring gene Fanconi anemia, complementation group G Neighboring gene STARR-positive B cell enhancer ABC_E6165 Neighboring gene STARR-positive B cell enhancer ABC_E1642 Neighboring gene STARR-positive B cell enhancer ABC_E9237 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene STARR-positive B cell enhancer ABC_E6166 Neighboring gene atos homolog B Neighboring gene STARR-seq mESC enhancer starr_10046 Neighboring gene unc-13 homolog B Neighboring gene STARR-seq mESC enhancer starr_10047 Neighboring gene predicted gene, 23709

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function. Fan R, et al. Biochem Biophys Res Commun, 2022 Dec 25. PMID 36332472
  2. Stomatin-like protein 2 deficiency results in impaired mitochondrial translation. Mitsopoulos P, et al. PLoS One, 2017. PMID 28654702, Free PMC Article
  3. Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Mitsopoulos P, et al. Mol Cell Biol, 2015 May. PMID 25776552, Free PMC Article
  4. Identification of mouse mslp2 gene from EST databases by repeated searching, comparison, and assembling. Chan WL, et al. Comput Biol Med, 2006 Jan. PMID 16324911
  5. Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans. Feng Q, et al. Reprod Biomed Online, 2017 Feb. PMID 27986413

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. resting or activated T cells from T cell-specific Slp-2 knockout mice showed a significant impairment in the production of several mitochondrial DNA-encoded polypeptides following T cell activation. Measurement of mitochondrial DNA stability and mitochondrial transcription revealed that this impairment was at the post-transcriptional level.
    Title: Stomatin-like protein 2 deficiency results in impaired mitochondrial translation.
  2. Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans
    Title: Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans.
  3. SLP-2 is an ABCA1-dependent regulator of raft composition and of the innate immune response.
    Title: Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
  4. Findings identify SLP-2 as a key regulator of the formation of respiratory chain supercomplex in vivo and show that these supercomplexes are required for optimal cell function.
    Title: Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables cardiolipin binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress-induced mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
stomatin-like protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419082.1 → NP_001406011.1  stomatin-like protein 2, mitochondrial isoform a

    Status: VALIDATED

    Source sequence(s)
    AL672276

  2. NM_001419083.1 → NP_001406012.1  stomatin-like protein 2, mitochondrial isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL672276

  3. NM_001419084.1 → NP_001406013.1  stomatin-like protein 2, mitochondrial isoform d

    Status: VALIDATED

    Source sequence(s)
    AL672276

  4. NM_001419085.1 → NP_001406014.1  stomatin-like protein 2, mitochondrial isoform e

    Status: VALIDATED

    Source sequence(s)
    AL672276
    Related
    ENSMUSP00000117586.2, ENSMUST00000136326.8

  5. NM_001419086.1 → NP_001406015.1  stomatin-like protein 2, mitochondrial isoform f

    Status: VALIDATED

    Source sequence(s)
    AL672276

  6. NM_001419087.1 → NP_001406016.1  stomatin-like protein 2, mitochondrial isoform f

    Status: VALIDATED

    Source sequence(s)
    AL672276

  7. NM_001419088.1 → NP_001406017.1  stomatin-like protein 2, mitochondrial isoform f

    Status: VALIDATED

    Source sequence(s)
    AL672276

  8. NM_023231.3 → NP_075720.1  stomatin-like protein 2, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_075720.1

    Status: VALIDATED

    Source sequence(s)
    AL672276
    Consensus CDS
    CCDS18089.1
    UniProtKB/Swiss-Prot
    Q99JB2, Q9DCG8
    UniProtKB/TrEMBL
    A2AG39
    Related
    ENSMUSP00000030169.9, ENSMUST00000030169.15
    Conserved Domains (2) summary
    COG0330
    Location:38 → 314
    HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]
    cd08829
    Location:74 → 184
    SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43027690..43031402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JB2.1 GenPept UniProtKB/Swiss-Prot:Q99JB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous