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Cmpk1 cytidine/uridine monophosphate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 66588, updated on 18-Apr-2024

Summary

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Official Symbol
Cmpk1provided by MGI
Official Full Name
cytidine/uridine monophosphate kinase 1provided by MGI
Primary source
MGI:MGI:1913838
See related
Ensembl:ENSMUSG00000028719 AllianceGenome:MGI:1913838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK; Cmpk; UMP-CMPk; 0610011D08Rik
Summary
Predicted to enable CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside phosphate metabolic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 43.9), colon adult (RPKM 37.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 52.73 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114817810..114844425, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (114960613..114987228, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene forkhead box E3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:114620034-114620334 Neighboring gene predicted gene, 40229 Neighboring gene STARR-positive B cell enhancer ABC_E2705 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114672416-114672599 Neighboring gene STARR-seq mESC enhancer starr_11107 Neighboring gene Scl/Tal1 interrupting locus Neighboring gene predicted gene, 52674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Liou JY, et al. Cancer Res, 2002 Mar 15. PMID 11912132
  2. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Kathiresan T, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423573, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CMP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables UMP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UMP kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables UMP/dUMP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cytidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside monophosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in dCDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dUDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleoside monophosphate phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UMP-CMP kinase
Names
UMP/CMPK
cytidine monophosphate (UMP-CMP) kinase 1
cytidine monophosphate kinase
cytidylate kinase 1
dCMP kinase
deoxycytidylate kinase
likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK)
nucleoside-diphosphate kinase
uridine monophosphate kinase
uridine monophosphate/cytidine monophosphate kinase
NP_079923.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025647.3 → NP_079923.3  UMP-CMP kinase

    See identical proteins and their annotated locations for NP_079923.3

    Status: VALIDATED

    Source sequence(s)
    AK002526, AK077534, AK150162, AV315242
    Consensus CDS
    CCDS18484.1
    UniProtKB/Swiss-Prot
    Q8BK17, Q8VD05, Q9DBP5, Q9DCS7
    UniProtKB/TrEMBL
    A0A0R4J093
    Related
    ENSMUSP00000030491.9, ENSMUST00000030491.9
    Conserved Domains (2) summary
    cd01428
    Location:36 → 215
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01359
    Location:36 → 224
    UMP_CMP_kin_fam; UMP-CMP kinase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    114817810..114844425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBP5.1 GenPept UniProtKB/Swiss-Prot:Q9DBP5

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