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Fastk Fas-activated serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 66587, updated on 11-Apr-2024

Summary

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Official Symbol
Fastkprovided by MGI
Official Full Name
Fas-activated serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:1913837
See related
Ensembl:ENSMUSG00000028959 AllianceGenome:MGI:1913837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
610011K02Rik; 0610011K02Rik
Summary
Predicted to enable RNA binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitochondrial RNA processing; protein phosphorylation; and regulation of RNA metabolic process. Predicted to act upstream of or within apoptotic process and phosphorylation. Located in nuclear speck. Is expressed in brain; gut; male reproductive gland or organ; metanephros; and thoracic segment skeleton. Orthologous to human FASTK (Fas activated serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 133.9), colon adult (RPKM 87.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 11.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24646036..24650280, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24441038..24445295, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 5 Neighboring gene acid-sensing ion channel 3 Neighboring gene STARR-positive B cell enhancer ABC_E9251 Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333 Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene VISTA enhancer mm1191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic ablation of fas-activated serine/threonine kinase ameliorates alcoholic liver disease through modulating HuR-SIRT1 mRNA complex stability. Zhang F, et al. Free Radic Biol Med, 2021 Apr. PMID 33610658
  2. Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy. Zhang F, et al. Redox Biol, 2021 Jan. PMID 33197770, Free PMC Article
  3. The Mitochondrial Isoform of FASTK Modulates Nonopsonic Phagocytosis of Bacteria by Macrophages via Regulation of Respiratory Complex I. García Del Río A, et al. J Immunol, 2018 Nov 15. PMID 30322967
  4. Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling. Zhang F, et al. Biochem Biophys Res Commun, 2020 Sep 3. PMID 32819566
  5. A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. Jourdain AA, et al. Cell Rep, 2015 Feb 24. PMID 25704814

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy.
    Title: Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy.
  2. Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling.
    Title: Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling.
  3. our results clearly demonstrate for the first time, to our knowledge, that mitoFASTK plays a negative regulatory role on nonopsonic phagocytosis of bacteria in macrophages through its action on mitochondrial respiratory complex I activity.
    Title: The Mitochondrial Isoform of FASTK Modulates Nonopsonic Phagocytosis of Bacteria by Macrophages via Regulation of Respiratory Complex I.
  4. In a well-established model of allergic pulmonary inflammation, FAST is a proinflammatory factor that modulates the function of lung resident hematopoietic cells to promote neutrophil recruitment and pulmonary inflammation.
    Title: Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Fas-activated serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fas-activated serine/threonine kinase
Names
FAST kinase
NP_075718.2
XP_017176555.1
XP_017176556.1
XP_030110621.1
XP_036021302.1
XP_036021303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023229.2 → NP_075718.2  fas-activated serine/threonine kinase

    See identical proteins and their annotated locations for NP_075718.2

    Status: VALIDATED

    Source sequence(s)
    AK152369
    Consensus CDS
    CCDS19120.1
    UniProtKB/TrEMBL
    Q8C725, Q8CAK5
    Related
    ENSMUSP00000030800.7, ENSMUST00000030800.13
    Conserved Domains (3) summary
    smart00952
    Location:480 → 532
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:274 → 339
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:354 → 439
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24646036..24650280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321066.2 → XP_017176555.1  fas-activated serine/threonine kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9JIX9
    UniProtKB/TrEMBL
    Q91WQ6
    Conserved Domains (3) summary
    smart00952
    Location:446 → 498
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:240 → 305
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:318 → 405
    FAST_2; FAST kinase-like protein, subdomain 2

  2. XM_036165410.1 → XP_036021303.1  fas-activated serine/threonine kinase isoform X2

    UniProtKB/TrEMBL
    E9QA06
    Conserved Domains (3) summary
    smart00952
    Location:332 → 384
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:126 → 191
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:204 → 291
    FAST_2; FAST kinase-like protein, subdomain 2

  3. XM_017321067.3 → XP_017176556.1  fas-activated serine/threonine kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9JIX9
    UniProtKB/TrEMBL
    Q91WQ6
    Conserved Domains (3) summary
    smart00952
    Location:446 → 498
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:240 → 305
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:318 → 405
    FAST_2; FAST kinase-like protein, subdomain 2

  4. XM_036165409.1 → XP_036021302.1  fas-activated serine/threonine kinase isoform X1

    UniProtKB/Swiss-Prot
    Q9JIX9
    UniProtKB/TrEMBL
    Q91WQ6
    Related
    ENSMUST00000149085.8
    Conserved Domains (3) summary
    smart00952
    Location:446 → 498
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:240 → 305
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:318 → 405
    FAST_2; FAST kinase-like protein, subdomain 2

  5. XM_030254761.2 → XP_030110621.1  fas-activated serine/threonine kinase isoform X2

    UniProtKB/TrEMBL
    E9QA06
    Related
    ENSMUSP00000110693.2, ENSMUST00000115041.2
    Conserved Domains (3) summary
    smart00952
    Location:332 → 384
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:126 → 191
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:204 → 291
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. XR_389748.5 RNA Sequence

  2. XR_003955693.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIX9.1 GenPept UniProtKB/Swiss-Prot:Q9JIX9

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