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Bod1l biorientation of chromosomes in cell division 1-like [ Mus musculus (house mouse) ]

Gene ID: 665775, updated on 5-Mar-2024

Summary

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Official Symbol
Bod1lprovided by MGI
Official Full Name
biorientation of chromosomes in cell division 1-likeprovided by MGI
Primary source
MGI:MGI:2444804
See related
Ensembl:ENSMUSG00000061755 AllianceGenome:MGI:2444804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FAM44A; mKIAA1327; A230054D04Rik
Summary
Predicted to enable protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Predicted to be involved in cellular response to DNA damage stimulus; negative regulation of phosphoprotein phosphatase activity; and replication fork processing. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of outer kinetochore. Predicted to be active in centrosome; spindle microtubule; and spindle pole. Orthologous to human BOD1L1 (biorientation of chromosomes in cell division 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.0), cerebellum adult (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bod1l in Genome Data Viewer
Location:
5 B3; 5 22.58 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (41944881..42001695, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (41787538..41844355, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F pseudogene Neighboring gene STARR-seq mESC enhancer starr_12949 Neighboring gene predicted gene, 46910 Neighboring gene NK3 homeobox 2 Neighboring gene STARR-positive B cell enhancer ABC_E11286 Neighboring gene tubulin polyglutamylase complex subunit 2 pseudogene Neighboring gene microRNA 6414

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Monoclonal antibodies recognize antigen expressed by osteoblasts. Benayahu D, et al. J Bone Miner Res, 1995 Oct. PMID 8686505
  2. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
biorientation of chromosomes in cell division protein 1-like 1
Names
family with sequence similarity 44, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081422.3 → NP_001074891.1  biorientation of chromosomes in cell division protein 1-like 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102858, AC157932
    Consensus CDS
    CCDS39079.1
    UniProtKB/Swiss-Prot
    E9Q6J5, O35243, Q3TR39, Q3USW6, Q80TF0, Q8BHG7
    Related
    ENSMUSP00000058618.8, ENSMUST00000050556.11
    Conserved Domains (2) summary
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
    pfam10310
    Location:183 → 280
    DUF2413; Protein of unknown function (DUF2413)

  2. NM_001310601.1 → NP_001297530.1  biorientation of chromosomes in cell division protein 1-like 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102858, AC157932
    Consensus CDS
    CCDS80273.1
    UniProtKB/Swiss-Prot
    E9Q6J5
    Related
    ENSMUSP00000144359.2, ENSMUST00000202908.2
    Conserved Domains (2) summary
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
    pfam10310
    Location:183 → 280
    DUF2413; Protein of unknown function (DUF2413)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    41944881..42001695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504050.5 → XP_006504113.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X1

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  2. XM_017321065.1 → XP_017176554.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X10

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  3. XM_006504055.5 → XP_006504118.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X8

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  4. XM_017321064.1 → XP_017176553.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X9

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  5. XM_006504054.5 → XP_006504117.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X7

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  6. XM_017321063.1 → XP_017176552.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X6

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  7. XM_036165408.1 → XP_036021301.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X4

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  8. XM_017321062.1 → XP_017176551.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X5

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  9. XM_006504053.3 → XP_006504116.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X3

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

  10. XM_006504051.3 → XP_006504114.1  biorientation of chromosomes in cell division protein 1-like 1 isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:303 → 1041
    PTZ00121; MAEBL; Provisional
    pfam05205
    Location:55 → 148
    COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q6J5.1 GenPept UniProtKB/Swiss-Prot:E9Q6J5

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