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Cenpm centromere protein M [ Mus musculus (house mouse) ]

Gene ID: 66570, updated on 21-Apr-2024

Summary

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Official Symbol
Cenpmprovided by MGI
Official Full Name
centromere protein Mprovided by MGI
Primary source
MGI:MGI:1913820
See related
Ensembl:ENSMUSG00000068101 AllianceGenome:MGI:1913820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pane1; 2610019I03Rik
Summary
This gene encodes a protein that is present in the nucleus of actively growing cells but is excluded from the nucleus during cell division or during growth arrest as a result of contact inhibition. In human, this protein is a component of the CENP-A nucleosome-associated complex that regulates kinetochore protein assembly, mitotic cell-cycle progression, and chromosome segregation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.4), thymus adult (RPKM 7.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 38.56 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82115694..82128974, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82233762..82244773, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene shisa family member 8 Neighboring gene STARR-positive B cell enhancer ABC_E2448 Neighboring gene tumor necrosis factor receptor superfamily, member 13c Neighboring gene STARR-positive B cell enhancer ABC_E8601 Neighboring gene STARR-seq mESC enhancer starr_39290 Neighboring gene small integral membrane protein 45 Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin. Renou JP, et al. Oncogene, 2003 Jul 17. PMID 12881717
  2. The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells. Bierie B, et al. Gene Expr Patterns, 2004 Jul. PMID 15183305
  3. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Hentges KE, et al. Genomics, 2002 Aug. PMID 12160734
  4. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Kumada T, et al. Dev Dyn, 2010 Aug. PMID 20568244
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing cells.
    Title: Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein M
Names
CENP-M
proliferation associated nuclear element 1
proliferation-associated nuclear element protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080158.1 → NP_001073627.1  centromere protein M isoform 3

    See identical proteins and their annotated locations for NP_001073627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI853711, AK011227, BG276334
    UniProtKB/Swiss-Prot
    Q9CQA0
    Conserved Domains (1) summary
    pfam11111
    Location:1 → 137
    CENP-M; Centromere protein M (CENP-M)

  2. NM_025639.4 → NP_079915.1  centromere protein M isoform 1

    See identical proteins and their annotated locations for NP_079915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI853711, AK011227, BY710734
    Consensus CDS
    CCDS27685.1
    UniProtKB/Swiss-Prot
    Q3THN3, Q91VS6, Q9CQA0
    Related
    ENSMUSP00000086560.4, ENSMUST00000089157.11
    Conserved Domains (1) summary
    pfam11111
    Location:1 → 172
    CENP-M; Centromere protein M (CENP-M)

  3. NM_178269.3 → NP_840000.2  centromere protein M isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI853711, AK011227, BY710734
    Consensus CDS
    CCDS37156.1
    UniProtKB/Swiss-Prot
    Q9CQA0
    Related
    ENSMUSP00000086558.5, ENSMUST00000089155.6
    Conserved Domains (1) summary
    pfam11111
    Location:1 → 110
    CENP-M; Centromere protein M (CENP-M)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82115694..82128974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248697.2 → XP_030104557.1  centromere protein M isoform X4

    Conserved Domains (1) summary
    pfam11111
    Location:1 → 78
    CENP-M; Centromere protein M (CENP-M)

  2. XM_036159540.1 → XP_036015433.1  centromere protein M isoform X5

    Conserved Domains (1) summary
    pfam11111
    Location:1 → 75
    CENP-M; Centromere protein M (CENP-M)

  3. XM_017316722.2 → XP_017172211.1  centromere protein M isoform X2

    Conserved Domains (1) summary
    pfam11111
    Location:1 → 140
    CENP-M; Centromere protein M (CENP-M)

  4. XM_006521260.5 → XP_006521323.1  centromere protein M isoform X3

    See identical proteins and their annotated locations for XP_006521323.1

    Conserved Domains (1) summary
    pfam11111
    Location:1 → 137
    CENP-M; Centromere protein M (CENP-M)

  5. XM_036159541.1 → XP_036015434.1  centromere protein M isoform X6

    Conserved Domains (1) summary
    pfam11111
    Location:13 → 106
    CENP-M; Centromere protein M (CENP-M)

  6. XM_011245710.4 → XP_011244012.1  centromere protein M isoform X1

    Conserved Domains (1) summary
    pfam11111
    Location:1 → 134
    CENP-M; Centromere protein M (CENP-M)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQA0.1 GenPept UniProtKB/Swiss-Prot:Q9CQA0

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