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Rwdd3 RWD domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 66568, updated on 5-Mar-2024

Summary

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Official Symbol
Rwdd3provided by MGI
Official Full Name
RWD domain containing 3provided by MGI
Primary source
MGI:MGI:1920420
See related
Ensembl:ENSMUSG00000028133 AllianceGenome:MGI:1920420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsume; X2CR1; 2510027J23Rik; 3110037C01Rik
Summary
Acts upstream of or within positive regulation of hypoxia-inducible factor-1alpha signaling pathway. Predicted to be located in cytoplasm and nucleus. Is expressed in cerebral cortex subventricular zone. Orthologous to human RWDD3 (RWD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 2.2), CNS E14 (RPKM 2.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G1; 3 52.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (120949046..120965427, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121155397..121171781, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6530403H02 gene Neighboring gene STARR-seq mESC enhancer starr_08831 Neighboring gene STARR-seq mESC enhancer starr_08832 Neighboring gene predicted gene, 52615 Neighboring gene STARR-seq mESC enhancer starr_08834 Neighboring gene STARR-seq mESC enhancer starr_08835 Neighboring gene predicted gene, 40133 Neighboring gene STARR-seq mESC enhancer starr_08836 Neighboring gene STARR-positive B cell enhancer ABC_E10209 Neighboring gene STARR-positive B cell enhancer ABC_E6110 Neighboring gene STARR-positive B cell enhancer ABC_E4583 Neighboring gene STARR-seq mESC enhancer starr_08837 Neighboring gene predicted gene 10652 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 52661 Neighboring gene TLC domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Carbia-Nagashima A, et al. Cell, 2007 Oct 19. PMID 17956732
  2. RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Shan B, et al. Endocr Relat Cancer, 2012 Feb. PMID 22009797
  3. Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. Kawaguchi A, et al. Development, 2008 Sep. PMID 18725516
  4. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
  5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC150017, MGC170967, MGC170969

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of hypoxia-inducible factor-1alpha signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hypoxia-inducible factor-1alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RWD domain-containing protein 3
Names
RWD domain-containing sumoylation enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025637.3 → NP_079913.2  RWD domain-containing protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK134288, BC037515, BY710389, BY744183
    Consensus CDS
    CCDS17799.2
    UniProtKB/TrEMBL
    E9Q1R6
    Related
    ENSMUSP00000102075.2, ENSMUST00000106467.8
    Conserved Domains (2) summary
    pfam05773
    Location:97 → 183
    RWD; RWD domain
    pfam06544
    Location:231 → 270
    DUF1115; Protein of unknown function (DUF1115)

  2. NM_028456.3 → NP_082732.2  RWD domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_082732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK134288, BC037515, BY744183
    Consensus CDS
    CCDS17798.1
    UniProtKB/TrEMBL
    A1A544, Q3UYX7
    Related
    ENSMUSP00000102074.4, ENSMUST00000106466.10
    Conserved Domains (2) summary
    pfam05773
    Location:3 → 111
    RWD; RWD domain
    pfam06544
    Location:146 → 258
    DUF1115; Protein of unknown function (DUF1115)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    120949046..120965427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240195.4 → XP_011238497.1  RWD domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011238497.1

    UniProtKB/TrEMBL
    A1A544, Q3UYX7
    Conserved Domains (2) summary
    pfam05773
    Location:3 → 111
    RWD; RWD domain
    pfam06544
    Location:146 → 258
    DUF1115; Protein of unknown function (DUF1115)

RNA

  1. XR_004941379.1 RNA Sequence

  2. XR_867227.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VIL2.1 GenPept UniProtKB/Swiss-Prot:Q8VIL2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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