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Drap1 DR1 associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66556, updated on 5-Mar-2024

Summary

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Official Symbol
Drap1provided by MGI
Official Full Name
DR1 associated protein 1provided by MGI
Primary source
MGI:MGI:1913806
See related
Ensembl:ENSMUSG00000024914 AllianceGenome:MGI:1913806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NC2-alpha; 2310074H19Rik
Summary
Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; and limb. Orthologous to human DRAP1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 92.7), CNS E11.5 (RPKM 65.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Drap1 in Genome Data Viewer
Location:
19 A; 19 4.32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5472832..5475007, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5422804..5424979, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54050 Neighboring gene RIKEN cDNA 4930481A15 gene Neighboring gene STARR-positive B cell enhancer ABC_E11669 Neighboring gene predicted pseudogene 6293 Neighboring gene STARR-positive B cell enhancer ABC_E8929 Neighboring gene expressed sequence AI837181 Neighboring gene predicted gene, 25432

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Trask MC, et al. Dev Biol, 2012 Aug 15. PMID 22669107, Free PMC Article
  2. Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Iratni R, et al. Science, 2002 Dec 6. PMID 12471260
  3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dr1-associated corepressor
Names
Dr1 associated protein 1 (negative cofactor 2 alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291080.1 → NP_001278009.1  dr1-associated corepressor isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122861, AK087456
    Consensus CDS
    CCDS70919.1
    UniProtKB/TrEMBL
    D3YY09, G3UXH5
    Related
    ENSMUSP00000109304.2, ENSMUST00000113674.8
    Conserved Domains (1) summary
    pfam00808
    Location:11 → 74
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

  2. NM_024176.2 → NP_077138.1  dr1-associated corepressor isoform 2

    See identical proteins and their annotated locations for NP_077138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC122861, AK087456
    Consensus CDS
    CCDS29462.1
    UniProtKB/Swiss-Prot
    Q9D6N5
    UniProtKB/TrEMBL
    G3UXH5, Q4FJW2
    Related
    ENSMUSP00000025853.10, ENSMUST00000025853.16
    Conserved Domains (1) summary
    pfam00808
    Location:11 → 74
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5472832..5475007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6N5.3 GenPept UniProtKB/Swiss-Prot:Q9D6N5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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