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Aggf1 angiogenic factor with G patch and FHA domains 1 [ Mus musculus (house mouse) ]

Gene ID: 66549, updated on 5-Mar-2024

Summary

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Official Symbol
Aggf1provided by MGI
Official Full Name
angiogenic factor with G patch and FHA domains 1provided by MGI
Primary source
MGI:MGI:1913799
See related
Ensembl:ENSMUSG00000021681 AllianceGenome:MGI:1913799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Peg3; VG5Q; 2010009L17Rik; 2310029P06Rik
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within angiogenesis and cell differentiation. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Is expressed in brain; egg cylinder; embryo mesoderm; genitourinary system; and primitive streak. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 16.3), CNS E11.5 (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aggf1 in Genome Data Viewer
Location:
13 D1; 13 49.41 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95487191..95511865, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95350683..95375357, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger, BED type containing 3 Neighboring gene predicted gene, 22661 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96117046-96117346 Neighboring gene predicted gene, 53806 Neighboring gene STARR-positive B cell enhancer ABC_E7266 Neighboring gene STARR-seq mESC enhancer starr_35322 Neighboring gene STARR-positive B cell enhancer ABC_E3093 Neighboring gene STARR-seq mESC enhancer starr_35323 Neighboring gene corticotropin releasing hormone binding protein Neighboring gene predicted gene, 52025 Neighboring gene S100 calcium binding protein, zeta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin α7 on vascular smooth muscle cells. Yu Y, et al. J Biol Chem, 2022 Apr. PMID 35202649, Free PMC Article
  2. Autophagy is required for the promoting effect of angiogenic factor with G patch domain and forkhead-associated domain 1 (AGGF1) in retinal angiogenesis. Li R, et al. Microvasc Res, 2021 Nov. PMID 34339727
  3. Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1. Si W, et al. FASEB J, 2018 Sep. PMID 29641288, Free PMC Article
  4. A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure. Yao Y, et al. Nat Commun, 2017 Jul 25. PMID 28743963, Free PMC Article
  5. Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury. Yao Y, et al. J Am Heart Assoc, 2017 Jun 25. PMID 28649088, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin alpha7 on vascular smooth muscle cells.
    Title: Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin α7 on vascular smooth muscle cells.
  2. Autophagy is required for the promoting effect of angiogenic factor with G patch domain and forkhead-associated domain 1 (AGGF1) in retinal angiogenesis.
    Title: Autophagy is required for the promoting effect of angiogenic factor with G patch domain and forkhead-associated domain 1 (AGGF1) in retinal angiogenesis.
  3. Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.
    Title: Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.
  4. The 3' Untranslated Region Protects the Heart from Angiotensin II-Induced Cardiac Dysfunction via AGGF1 Expression.
    Title: The 3' Untranslated Region Protects the Heart from Angiotensin II-Induced Cardiac Dysfunction via AGGF1 Expression.
  5. Aggf1 over-expression blocks liver fibrosis and Hepatic stellate cells (HSCs) activation. Aggf1 interacts with SMAD7 to suppress TGF signaling. DNA methylation regulates liver fibrosis and HSC activation by targeting Aggf1.
    Title: Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-β signaling.
  6. AGGF1 protein therapy is effective in blocking neointimal formation after vascular injury by regulating a novel AGGF1-MEK1/2-ERK1/2-Elk-myocardin-SRF/p27 signaling pathway.
    Title: Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury.
  7. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)
    Title: Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.
  8. Data indicate that angiogenic factor Aggf1+/- knockout (KO) mice show reduced autophagy, which was associated with inhibition of angiogenesis and larger infarct areas.
    Title: Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.
  9. Mechanistically, Aggf1 activated the expression of gluconeogenesis gene and skewed the insulin signaling pathway to induce insulin resistance. Taken together, our data suggest that Aggf1 plays a role in steatosis in vivo and as such may be a new target in the development of therapeutics solutions against steatosis.
    Title: Angiogenic factor with G patch and FHA domains 1 (Aggf1) promotes hepatic steatosis in mice.
  10. Sphingolipid modulation of angiogenic factor expression in neuroblastoma
    Title: Sphingolipid modulation of angiogenic factor expression in neuroblastoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
angiogenic factor with G patch and FHA domains 1
Names
angiogenic factor VG5Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025630.3 → NP_079906.2  angiogenic factor with G patch and FHA domains 1

    See identical proteins and their annotated locations for NP_079906.2

    Status: VALIDATED

    Source sequence(s)
    AA138180, AK132575, BC052410
    Consensus CDS
    CCDS26697.1
    UniProtKB/Swiss-Prot
    Q7TN31, Q8R2S6, Q9CQR9, Q9CU87, Q9D768
    UniProtKB/TrEMBL
    Q3V1B3
    Related
    ENSMUSP00000022189.9, ENSMUST00000022189.9
    Conserved Domains (4) summary
    COG1716
    Location:424 → 509
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:407 → 513
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam01585
    Location:617 → 658
    G-patch; G-patch domain
    cd16164
    Location:200 → 253
    OCRE_VG5Q; OCRE domain found in angiogenic factor VG5Q and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95487191..95511865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN31.1 GenPept UniProtKB/Swiss-Prot:Q7TN31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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