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Adamtsl5 ADAMTS-like 5 [ Mus musculus (house mouse) ]

Gene ID: 66548, updated on 5-Mar-2024

Summary

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Official Symbol
Adamtsl5provided by MGI
Official Full Name
ADAMTS-like 5provided by MGI
Primary source
MGI:MGI:1913798
See related
Ensembl:ENSMUSG00000043822 AllianceGenome:MGI:1913798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thsd6; 2010109H09Rik
Summary
Predicted to enable heparin binding activity and microfibril binding activity. Located in extracellular matrix. Is expressed in several structures, including alimentary system; liver and biliary system; mesothelium; musculoskeletal system; and sensory organ. Orthologous to human ADAMTSL5 (ADAMTS like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 43.1), small intestine adult (RPKM 30.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Adamtsl5 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80175655..80184246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80339793..80349030, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene STARR-positive B cell enhancer ABC_E366 Neighboring gene predicted gene, 51809 Neighboring gene receptor accessory protein 6 Neighboring gene polo like kinase 5 Neighboring gene mex3 RNA binding family member D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. Bader HL, et al. Matrix Biol, 2012 Sep-Oct. PMID 23010571, Free PMC Article
  2. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  3. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC41037

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables microfibril binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 5
Names
thrombospondin, type I domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285435.2 → NP_001272364.1  ADAMTS-like protein 5 precursor

    See identical proteins and their annotated locations for NP_001272364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS48628.1
    UniProtKB/TrEMBL
    D3Z689
    Related
    ENSMUSP00000093097.4, ENSMUST00000095446.10
    Conserved Domains (3) summary
    smart00209
    Location:49 → 98
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:379 → 478
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:207 → 312
    ADAM_spacer1; ADAM-TS Spacer 1

RNA

  1. NR_104339.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' region and an additional segment in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5' most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC152062

  2. NR_104340.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5' most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC152062
    Related
    ENSMUST00000124789.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80175655..80184246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243528.2 → XP_011241830.1  ADAMTS-like protein 5 isoform X3

    Conserved Domains (3) summary
    smart00209
    Location:48 → 97
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:378 → 477
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206 → 311
    ADAM_spacer1; ADAM-TS Spacer 1

  2. XM_011243526.4 → XP_011241828.1  ADAMTS-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011241828.1

    Conserved Domains (3) summary
    smart00209
    Location:112 → 161
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:442 → 541
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:270 → 375
    ADAM_spacer1; ADAM-TS Spacer 1

  3. XM_011243527.2 → XP_011241829.1  ADAMTS-like protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011241829.1

    UniProtKB/TrEMBL
    D3Z689
    Conserved Domains (3) summary
    smart00209
    Location:49 → 98
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:379 → 478
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:207 → 312
    ADAM_spacer1; ADAM-TS Spacer 1

RNA

  1. XR_001779576.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001113548.1: Suppressed sequence

    Description
    NM_001113548.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  2. NM_025629.2: Suppressed sequence

    Description
    NM_025629.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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