Plb1 phospholipase B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plb1provided by MGI
Official Full Name: phospholipase B1provided by MGI
Primary source: MGI:MGI:1922406
See related: Ensembl:ENSMUSG00000029134 AllianceGenome:MGI:1922406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4632413E21Rik; 4930433E17Rik; 4930539A06Rik
Summary: Predicted to enable carboxylic ester hydrolase activity. Acts upstream of or within positive regulation of acrosome reaction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in brush border membrane. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantle layer; lung; midbrain mantle layer; and telencephalon mantle layer. Orthologous to human PLB1 (phospholipase B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 54.9), testis adult (RPKM 15.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.33 cM

Exon count:: 61

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (32390035..32521700)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (32232691..32364356)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathogenicity of phospholipase B1 of Trichosporon asahii in immunosuppressed mice.
Title: Pathogenicity of phospholipase B1 of Trichosporon asahii in immunosuppressed mice.
sperm surface phospholipase B is activated in response to sterol removal
Title: Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	IEA Inferred from Electronic Annotation more info
enables retinyl-palmitate esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinyl-palmitate esterase activity	ISO Inferred from Sequence Orthology more info
enables triglyceride lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in diacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase B1, membrane-associated

Names: PLB/LIP; lysophospholipase; phospholipase A2; phospholipase B; phospholipase B/lipase; triacylglycerol lipase

NP_001074876.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

NP_084348.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

NP_742159.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_006504110.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_006504111.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_006504112.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081407.1 → NP_001074876.1 phospholipase B1, membrane-associated isoform 1 precursor

See identical proteins and their annotated locations for NP_001074876.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).

Source sequence(s)

AC102372, AK087596, AK161095, BC119077

Consensus CDS

CCDS39060.1

UniProtKB/Swiss-Prot

Q0VEX7, Q3TTY0, Q9D4Y6

Conserved Domains (1) summary

cd01824
Location:387 → 681

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
NM_030072.1 → NP_084348.1 phospholipase B1, membrane-associated isoform 2

See identical proteins and their annotated locations for NP_084348.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has shorter N- and C-termini when compared to isoform 1.

Source sequence(s)

AK030142

UniProtKB/Swiss-Prot

Q3TTY0

Related

ENSMUST00000202886.4

Conserved Domains (2) summary

cd01824
Location:292 → 586

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...

cl01053
Location:9 → 226

SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
NM_172147.2 → NP_742159.1 phospholipase B1, membrane-associated isoform 3

See identical proteins and their annotated locations for NP_742159.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains only a small portion of the 3' end of variant 1 and uses a downstream start codon to encode a much shorter protein (isoform 3) when it is compared to isoform 1.

Source sequence(s)

AK087596

UniProtKB/TrEMBL

Q8K255

Conserved Domains (1) summary

cl01053
Location:1 → 84

SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

32390035..32521700

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504047.2 → XP_006504110.1 phospholipase B1, membrane-associated isoform X1

See identical proteins and their annotated locations for XP_006504110.1

UniProtKB/Swiss-Prot

Q0VEX7, Q3TTY0, Q9D4Y6

Related

ENSMUSP00000144040.2, ENSMUST00000202220.4

Conserved Domains (1) summary

cd01824
Location:387 → 681

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
XM_006504048.2 → XP_006504111.1 phospholipase B1, membrane-associated isoform X2

Conserved Domains (1) summary

cd01824
Location:387 → 681

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
XM_006504049.5 → XP_006504112.1 phospholipase B1, membrane-associated isoform X3

Conserved Domains (1) summary

cd01824
Location:1 → 273

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...