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Pgpep1 pyroglutamyl-peptidase I [ Mus musculus (house mouse) ]

Gene ID: 66522, updated on 5-Mar-2024

Summary

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Official Symbol
Pgpep1provided by MGI
Official Full Name
pyroglutamyl-peptidase Iprovided by MGI
Primary source
MGI:MGI:1913772
See related
Ensembl:ENSMUSG00000056204 AllianceGenome:MGI:1913772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGP; Pcp; PGPI; PAP-I; PGP-I; Gm19458; 2810003H13Rik
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in alimentary system; central nervous system; genitourinary system; and lung. Orthologous to human PGPEP1 (pyroglutamyl-peptidase I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 36.5), adrenal adult (RPKM 16.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71099086..71113096, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70646436..70660446, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6645 Neighboring gene STARR-seq mESC enhancer starr_21778 Neighboring gene growth differentiation factor 15 Neighboring gene predicted gene, 34154 Neighboring gene STARR-seq mESC enhancer starr_21782 Neighboring gene STARR-positive B cell enhancer ABC_E10505 Neighboring gene STARR-positive B cell enhancer ABC_E6646 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73197019-73197273 Neighboring gene LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene predicted gene, 39191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme. Dando PM, et al. Protein Expr Purif, 2003 Mar. PMID 12651114
  2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning and sequencing of the mouse (AJ278829) pyroglutamyl-peptidase I
    Title: Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables pyroglutamyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyroglutamyl-peptidase 1
Names
5-oxoprolyl-peptidase
putative pyroglutamyl-peptidase I
pyroglutamyl aminopeptidase I
pyrrolidone-carboxylate peptidase
NP_075706.1
XP_006509782.1
XP_030099578.1
XP_030099579.1
XP_030099580.1
XP_030099581.1
XP_030099582.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023217.4 → NP_075706.1  pyroglutamyl-peptidase 1

    See identical proteins and their annotated locations for NP_075706.1

    Status: VALIDATED

    Source sequence(s)
    AC157774, AC166931, BC051938, BY313315
    Consensus CDS
    CCDS22377.1
    UniProtKB/Swiss-Prot
    Q9ESW8
    Related
    ENSMUSP00000070778.8, ENSMUST00000070173.9
    Conserved Domains (1) summary
    cd00501
    Location:6 → 199
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71099086..71113096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243719.1 → XP_030099579.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSC4
    Conserved Domains (1) summary
    cl00237
    Location:1 → 122
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  2. XM_030243722.2 → XP_030099582.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSC4
    Conserved Domains (1) summary
    cl00237
    Location:1 → 122
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  3. XM_006509719.5 → XP_006509782.1  pyroglutamyl-peptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509782.1

    Conserved Domains (1) summary
    cd00501
    Location:6 → 160
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  4. XM_030243718.2 → XP_030099578.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSC4
    Conserved Domains (1) summary
    cl00237
    Location:1 → 122
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  5. XM_030243721.2 → XP_030099581.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSC4
    Conserved Domains (1) summary
    cl00237
    Location:1 → 122
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  6. XM_030243720.2 → XP_030099580.1  pyroglutamyl-peptidase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GSC4
    Related
    ENSMUSP00000147879.2, ENSMUST00000210307.2
    Conserved Domains (1) summary
    cl00237
    Location:1 → 122
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESW8.1 GenPept UniProtKB/Swiss-Prot:Q9ESW8

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