Asrgl1 asparaginase like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asrgl1provided by MGI
Official Full Name: asparaginase like 1provided by MGI
Primary source: MGI:MGI:1913764
See related: Ensembl:ENSMUSG00000024654 AllianceGenome:MGI:1913764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ALP; ALP1; 2410004D18Rik
Summary: Predicted to enable asparaginase activity and beta-aspartyl-peptidase activity. Predicted to be involved in asparagine catabolic process via L-aspartate. Predicted to act upstream of or within proteolysis. Located in photoreceptor inner segment. Is expressed in alimentary system; cranium; nervous system; and respiratory system. Orthologous to human ASRGL1 (asparaginase and isoaspartyl peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 166.3), frontal lobe adult (RPKM 27.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.06 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (9089083..9112930, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (9111719..9135566, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype.
Title: A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD) Recapitulating the Human Phenotype.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW060375 (e-PCR)
- UniSTS:181192

AU040643 (e-PCR)
- UniSTS:181195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables asparaginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables asparaginase activity	ISO Inferred from Sequence Orthology more info
enables beta-aspartyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-aspartyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in asparagine catabolic process via L-aspartate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within asparagine catabolic process via L-aspartate	ISO Inferred from Sequence Orthology more info
involved_in asparagine catabolic process via L-aspartate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: isoaspartyl peptidase/L-asparaginase

Names: L-asparaginase; L-asparagine amidohydrolase; asparaginase-like protein 1; beta-aspartyl-peptidase; isoaspartyl dipeptidase

NP_079886.2

EC 3.4.19.5

EC 3.5.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025610.3 → NP_079886.2 isoaspartyl peptidase/L-asparaginase

See identical proteins and their annotated locations for NP_079886.2

Status: PROVISIONAL

Source sequence(s)

AK030209

Consensus CDS

CCDS29566.1

UniProtKB/Swiss-Prot

Q8C0M9, Q91WC8, Q9CVX3

Related

ENSMUSP00000051709.5, ENSMUST00000049948.6

Conserved Domains (2) summary

PRK10226
Location:21 → 300

PRK10226; isoaspartyl peptidase; Provisional

cd04702
Location:19 → 308

ASRGL1_like; Metazoan L-Asparaginase type 2