Nova1 NOVA alternative splicing regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nova1provided by MGI
Official Full Name: NOVA alternative splicing regulator 1provided by MGI
Primary source: MGI:MGI:104297
See related: Ensembl:ENSMUSG00000021047 AllianceGenome:MGI:104297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nova-1; G630039L02; 9430099M15Rik
Summary: Enables mRNA 3'-UTR binding activity and sequence-specific mRNA binding activity. Involved in negative regulation of cold-induced thermogenesis and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within mRNA splicing, via spliceosome and regulation of RNA metabolic process. Located in nucleus. Is expressed in several structures, including nervous system and retina. Orthologous to human NOVA1 (NOVA alternative splicing regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 9.0), CNS E14 (RPKM 7.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B3; 12 21.46 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (46744678..46866143, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (46697895..46819480, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons.
Title: NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons.
Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.
Title: Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice.
Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.
Title: Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis.
MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1.
Title: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1.
a major role for NOVA in regulating cytoskeleton interactions in motoneurons, is reported.
Title: Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons.
Together, these results demonstrate that the production of DCC splice variants controlled by NOVA has a crucial function during many stages of commissural neuron development.
Title: NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.
Phenotypic analysis of the NOVA-deficient mice demonstrated increased adipose tissue thermogenesis and improved glycemia.
Title: An alternative splicing program promotes adipose tissue thermogenesis.
RBM4a ablation enhanced the relative level of exon 4-excluded neuro-oncological ventral antigen 1 (Nova1(-4)) transcripts, which were predominantly generated in embryonic BAs
Title: RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.
identify Nova-1 and hnRNP M as D2R pre-mRNA-binding proteins and show their antagonistic role in the alternative splicing of D2R pre-mRNA.
Title: Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
integrative network revealed combinatorial regulation by Nova and the neuronal splicing factor Fox, interplay between phosphorylation and splicing, and potential links to neurologic disease
Title: Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NOVA1__6065 (e-PCR)
- UniSTS:463641

D12Dcr1 (e-PCR), detects polymorphism
- UniSTS:507483

NoName (e-PCR)
- UniSTS:492163

D12Mit112 (e-PCR), detects polymorphism
- UniSTS:126662

Nova1 (e-PCR), detects polymorphism
- UniSTS:479181

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of RNA metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding protein Nova-1

Names: neuro-oncological ventral antigen 1; ventral neuron-specific protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364634.1 → NP_001351563.1 RNA-binding protein Nova-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC108802, AC156636, CT009504

Conserved Domains (1) summary

cl00098
Location:49 → 121

KH-I; K homology (KH) RNA-binding domain, type I
NM_001364635.1 → NP_001351564.1 RNA-binding protein Nova-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC108802, AC156636, CT009504

Conserved Domains (2) summary

cd00105
Location:398 → 463

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:148 → 213

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001364636.1 → NP_001351565.1 RNA-binding protein Nova-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC108802, AC156636, CT009504

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
NM_001364637.1 → NP_001351566.1 RNA-binding protein Nova-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC108802, AC156636, CT009504

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
NM_001364638.1 → NP_001351567.1 RNA-binding protein Nova-1 isoform 5

Status: VALIDATED

Source sequence(s)

AC108802, AC156636, CT009504

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:276 → 346

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:26 → 95

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
NM_001364639.1 → NP_001351568.1 RNA-binding protein Nova-1 isoform 6

Status: VALIDATED

Source sequence(s)

AC108802, AC156636

Conserved Domains (1) summary

cd02396
Location:51 → 117

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_021361.2 → NP_067336.1 RNA-binding protein Nova-1 isoform 1

See identical proteins and their annotated locations for NP_067336.1

Status: VALIDATED

Source sequence(s)

AC108802, AW491473, BM942596, CT009504

Consensus CDS

CCDS49058.1

UniProtKB/Swiss-Prot

Q8C8B9, Q9JKN6

Related

ENSMUSP00000021438.7, ENSMUST00000021438.8

Conserved Domains (1) summary

cl00098
Location:49 → 121

KH-I; K homology (KH) RNA-binding domain, type I

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

46744678..46866143 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315157.2 → XP_017170646.1 RNA-binding protein Nova-1 isoform X9

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157578.1 → XP_036013471.1 RNA-binding protein Nova-1 isoform X12

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:250 → 320

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:2 → 69

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157571.1 → XP_036013464.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246862.2 → XP_030102722.1 RNA-binding protein Nova-1 isoform X9

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157568.1 → XP_036013461.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157579.1 → XP_036013472.1 RNA-binding protein Nova-1 isoform X12

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:250 → 320

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:2 → 69

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157577.1 → XP_036013470.1 RNA-binding protein Nova-1 isoform X12

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:250 → 320

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:2 → 69

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246863.1 → XP_030102723.1 RNA-binding protein Nova-1 isoform X9

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157569.1 → XP_036013462.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246865.1 → XP_030102725.1 RNA-binding protein Nova-1 isoform X9

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157572.1 → XP_036013465.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157566.1 → XP_036013459.1 RNA-binding protein Nova-1 isoform X5

Conserved Domains (3) summary

cd09031
Location:381 → 451

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:8 → 80

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:131 → 200

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157563.1 → XP_036013456.1 RNA-binding protein Nova-1 isoform X3

Conserved Domains (3) summary

cd09031
Location:404 → 474

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:8 → 80

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:156 → 223

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157564.1 → XP_036013457.1 RNA-binding protein Nova-1 isoform X3

Conserved Domains (3) summary

cd09031
Location:404 → 474

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:8 → 80

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:156 → 223

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157573.1 → XP_036013466.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157565.1 → XP_036013458.1 RNA-binding protein Nova-1 isoform X3

Conserved Domains (3) summary

cd09031
Location:404 → 474

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:8 → 80

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:156 → 223

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246859.2 → XP_030102719.1 RNA-binding protein Nova-1 isoform X7

Conserved Domains (2) summary

cd00105
Location:358 → 423

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:108 → 173

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
XM_030246868.1 → XP_030102728.1 RNA-binding protein Nova-1 isoform X11

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:276 → 346

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:26 → 95

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246864.1 → XP_030102724.1 RNA-binding protein Nova-1 isoform X9

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157570.1 → XP_036013463.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157574.1 → XP_036013467.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246866.2 → XP_030102726.1 RNA-binding protein Nova-1 isoform X9

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:300 → 370

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:50 → 119

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157575.1 → XP_036013468.1 RNA-binding protein Nova-1 isoform X10

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:280 → 350

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:32 → 99

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_030246857.2 → XP_030102717.1 RNA-binding protein Nova-1 isoform X6

Conserved Domains (3) summary

cd09031
Location:361 → 431

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:12 → 84

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:111 → 180

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_006516151.4 → XP_006516214.1 RNA-binding protein Nova-1 isoform X4

See identical proteins and their annotated locations for XP_006516214.1

Conserved Domains (1) summary

cl00098
Location:12 → 84

KH-I; K homology (KH) RNA-binding domain, type I
XM_036157562.1 → XP_036013455.1 RNA-binding protein Nova-1 isoform X2

Conserved Domains (3) summary

cd09031
Location:408 → 478

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:12 → 84

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:160 → 227

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157576.1 → XP_036013469.1 RNA-binding protein Nova-1 isoform X12

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:250 → 320

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:2 → 69

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157561.1 → XP_036013454.1 RNA-binding protein Nova-1 isoform X1

Conserved Domains (3) summary

cd09031
Location:445 → 515

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:49 → 121

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:197 → 264

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
XM_036157567.1 → XP_036013460.1 RNA-binding protein Nova-1 isoform X8

UniProtKB/TrEMBL

A3KMK7

Conserved Domains (2) summary

cd09031
Location:323 → 393

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:75 → 142

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)