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Exoc2 exocyst complex component 2 [ Mus musculus (house mouse) ]

Gene ID: 66482, updated on 11-Apr-2024

Summary

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Official Symbol
Exoc2provided by MGI
Official Full Name
exocyst complex component 2provided by MGI
Primary source
MGI:MGI:1913732
See related
Ensembl:ENSMUSG00000021357 AllianceGenome:MGI:1913732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec5; Sec5l1; Gm29675; 2410030I24Rik
Summary
Enables protein N-terminus binding activity and small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and regulation of entry of bacterium into host cell. Predicted to act upstream of or within positive regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.5), CNS E14 (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.2; 13
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30968421..31162082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30789516..30974096, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5386 Neighboring gene dual specificity phosphatase 22 Neighboring gene STARR-seq mESC enhancer starr_34069 Neighboring gene STARR-positive B cell enhancer ABC_E10787 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:30853140-30853323 Neighboring gene interferon regulatory factor 4 Neighboring gene STARR-positive B cell enhancer ABC_E11781 Neighboring gene HUS1 checkpoint clamp component B Neighboring gene predicted gene, 35302 Neighboring gene RIKEN cDNA 4930401O12 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. Xie L, et al. PLoS One, 2013. PMID 23844030, Free PMC Article
  2. Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. Mott HR, et al. J Biol Chem, 2003 May 9. PMID 12624092
  3. Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Nichols CD, et al. Curr Biol, 2010 Jul 27. PMID 20579884, Free PMC Article
  4. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Saito T, et al. Biomed Res, 2008 Apr. PMID 18480549
  5. Arl13b and the exocyst interact synergistically in ciliogenesis. Seixas C, et al. Mol Biol Cell, 2016 Jan 15. PMID 26582389, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
    Title: Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
  2. the structure of the Ral-binding domain of Sec5
    Title: Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of exocytosis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of entry of bacterium into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering involved in exocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst ISO
Inferred from Sequence Orthology
more info
  
part_of exocyst NAS
Non-traceable Author Statement
more info
 PubMed 
part_of exocyst TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
exocyst complex component 2
Names
SEC5 homolog
SEC5-like 1
exocyst complex component Sec5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360093.1 → NP_001347022.1  exocyst complex component 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606764, AL645745
    Consensus CDS
    CCDS26420.1
    UniProtKB/Swiss-Prot
    Q9D4H1
    Related
    ENSMUSP00000100010.2, ENSMUST00000102946.8
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

  2. NM_001424702.1 → NP_001411631.1  exocyst complex component 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606764, AL645745

  3. NM_025588.2 → NP_079864.1  exocyst complex component 2 isoform 1

    See identical proteins and their annotated locations for NP_079864.1

    Status: VALIDATED

    Source sequence(s)
    BC049102
    Consensus CDS
    CCDS26420.1
    UniProtKB/Swiss-Prot
    Q9D4H1
    Related
    ENSMUSP00000021785.7, ENSMUST00000021785.8
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30968421..31162082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244328.3 → XP_011242630.1  exocyst complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

  2. XM_036158115.1 → XP_036014008.1  exocyst complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

  3. XM_036158116.1 → XP_036014009.1  exocyst complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

  4. XM_036158117.1 → XP_036014010.1  exocyst complex component 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9D4H1
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

  5. XM_017315565.3 → XP_017171054.1  exocyst complex component 2 isoform X4

    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 374
    Sec5; Exocyst complex component Sec5

  6. XM_017315564.3 → XP_017171053.1  exocyst complex component 2 isoform X3

    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 374
    Sec5; Exocyst complex component Sec5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4H1.1 GenPept UniProtKB/Swiss-Prot:Q9D4H1

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