Prxl2b peroxiredoxin like 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prxl2bprovided by MGI
Official Full Name: peroxiredoxin like 2Bprovided by MGI
Primary source: MGI:MGI:1913719
See related: Ensembl:ENSMUSG00000029059 AllianceGenome:MGI:1913719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam213b; PM/PGFS; 2810405K02Rik
Summary: Enables prostaglandin-F synthase activity. Involved in prostaglandin biosynthetic process. Located in cytosol; endoplasmic reticulum; and myelin sheath. Is expressed in thymus primordium. Orthologous to human PRXL2B (peroxiredoxin like 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 57.4), small intestine adult (RPKM 50.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 85.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (154980884..154983522, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (154896430..154899043, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure.
Title: Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI836168 (e-PCR)
- UniSTS:165377

NoName (e-PCR)
- UniSTS:225322

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-F synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-F synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prostaglandin-F synthase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables thioredoxin peroxidase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
NOT colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostamide/prostaglandin F synthase

Names: family with sequence similarity 213, member B; prostamide/PG F synthase; prostamide/PGF synthase

NP_079858.2

EC 1.11.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025582.4 → NP_079858.2 prostamide/prostaglandin F synthase

See identical proteins and their annotated locations for NP_079858.2

Status: VALIDATED

Source sequence(s)

AL607032

Consensus CDS

CCDS19016.1

UniProtKB/Swiss-Prot

Q9DB60

Related

ENSMUSP00000030935.4, ENSMUST00000030935.10

Conserved Domains (1) summary

cd02970
Location:8 → 167

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...