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Taf12 TATA-box binding protein associated factor 12 [ Mus musculus (house mouse) ]

Gene ID: 66464, updated on 5-Mar-2024

Summary

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Official Symbol
Taf12provided by MGI
Official Full Name
TATA-box binding protein associated factor 12provided by MGI
Primary source
MGI:MGI:1913714
See related
Ensembl:ENSMUSG00000028899 AllianceGenome:MGI:1913714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
20kDa; Taf2J; 2810422D08Rik
Summary
Enables DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; histone H3 acetylation; and regulation of transcription, DNA-templated. Located in nucleus. Part of SAGA complex. Is expressed in early conceptus; limb; oocyte; and tail. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Taf12 in Genome Data Viewer
Location:
4 D2.3; 4 65.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132001667..132020640)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132274355..132293329)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene predicted gene 28874 Neighboring gene STARR-positive B cell enhancer ABC_E3519 Neighboring gene U11 small nuclear RNA Neighboring gene STARR-positive B cell enhancer ABC_E6228 Neighboring gene RAB42, member RAS oncogene family Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA host gene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping. Sun F, et al. Genes Dev, 2021 Aug 1. PMID 34301767, Free PMC Article
  2. Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). Werten S, et al. J Biol Chem, 2002 Nov 22. PMID 12237304
  3. Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease. Teramachi J, et al. J Bone Miner Res, 2013 Jun. PMID 23426901, Free PMC Article
  4. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Frock RL, et al. Genes Dev, 2006 Feb 15. PMID 16481476, Free PMC Article
  5. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.
    Title: The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.
  2. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
    Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 12
Names
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa
TAFII-20
TAFII20
transcription initiation factor TFIID 20 kDa subunits

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025579.3 → NP_079855.2  transcription initiation factor TFIID subunit 12

    See identical proteins and their annotated locations for NP_079855.2

    Status: VALIDATED

    Source sequence(s)
    AK132927, AK139748, BE630738, BY069348
    Consensus CDS
    CCDS18721.1
    UniProtKB/Swiss-Prot
    Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0
    UniProtKB/TrEMBL
    Q3UT56
    Related
    ENSMUSP00000030731.5, ENSMUST00000030731.11
    Conserved Domains (1) summary
    cd07981
    Location:58 → 126
    TAF12; TATA Binding Protein (TBP) Associated Factor 12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132001667..132020640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539110.3 → XP_006539173.1  transcription initiation factor TFIID subunit 12 isoform X3

    See identical proteins and their annotated locations for XP_006539173.1

    UniProtKB/Swiss-Prot
    Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0
    UniProtKB/TrEMBL
    Q3UT56
    Conserved Domains (1) summary
    cd07981
    Location:58 → 126
    TAF12; TATA Binding Protein (TBP) Associated Factor 12

  2. XM_006539109.2 → XP_006539172.1  transcription initiation factor TFIID subunit 12 isoform X3

    See identical proteins and their annotated locations for XP_006539172.1

    UniProtKB/Swiss-Prot
    Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0
    UniProtKB/TrEMBL
    Q3UT56
    Conserved Domains (1) summary
    cd07981
    Location:58 → 126
    TAF12; TATA Binding Protein (TBP) Associated Factor 12

  3. XM_036164314.1 → XP_036020207.1  transcription initiation factor TFIID subunit 12 isoform X2

    UniProtKB/TrEMBL
    E9QNT5
    Related
    ENSMUSP00000101583.2, ENSMUST00000105963.2
    Conserved Domains (1) summary
    cd07981
    Location:110 → 178
    TAF12; TATA Binding Protein (TBP) Associated Factor 12

  4. XM_017320350.2 → XP_017175839.2  transcription initiation factor TFIID subunit 12 isoform X1

    UniProtKB/TrEMBL
    Q3UT56
    Conserved Domains (1) summary
    cd07981
    Location:92 → 160
    TAF12; TATA Binding Protein (TBP) Associated Factor 12
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE65.1 GenPept UniProtKB/Swiss-Prot:Q8VE65

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