Pam16 presequence translocase-asssociated motor 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pam16provided by MGI
Official Full Name: presequence translocase-asssociated motor 16provided by MGI
Primary source: MGI:MGI:1913699
See related: Ensembl:ENSMUSG00000014301 AllianceGenome:MGI:1913699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tim16; Magmas; Timm16; CGI-136; 2010110I09Rik
Summary: Acts upstream of or within DNA biosynthetic process and negative regulation of apoptotic signaling pathway. Located in mitochondrion. Part of PAM complex, Tim23 associated import motor. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and lung. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Megarbane-Dagher-Melike type. Orthologous to human PAM16 (presequence translocase associated motor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 60.5), thymus adult (RPKM 48.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4434330..4442810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4616466..4624946, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IDA Inferred from Direct Assay more info	PubMed
part_of PAM complex, Tim23 associated import motor	ISO Inferred from Sequence Orthology more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with matrix side of mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit TIM16

Names: magmas processed gene 1; mitochondria associated granulocyte macrophage CSF signaling molecule; mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction; presequence translocase-asssociated motor 16 homolog; presequence translocated-associated motor subunit PAM16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.