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Mgst3 microsomal glutathione S-transferase 3 [ Mus musculus (house mouse) ]

Gene ID: 66447, updated on 5-Mar-2024

Summary

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Official Symbol
Mgst3provided by MGI
Official Full Name
microsomal glutathione S-transferase 3provided by MGI
Primary source
MGI:MGI:1913697
See related
Ensembl:ENSMUSG00000026688 AllianceGenome:MGI:1913697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GST-III; 2010012L10Rik; 2010306B17Rik; 2700004G04Rik
Summary
Predicted to enable several functions, including glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in leukotriene biosynthetic process and lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Is expressed in several structures, including alimentary system; integumental system; liver; nervous system; and sensory organ. Orthologous to human MGST3 (microsomal glutathione S-transferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 1980.6), duodenum adult (RPKM 1260.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Mgst3 in Genome Data Viewer
Location:
1 H2.3; 1 74.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167199535..167221410, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167371966..167393841, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8779 Neighboring gene STARR-positive B cell enhancer ABC_E2583 Neighboring gene predicted gene, 24182 Neighboring gene aldehyde dehydrogenase 9, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E4378 Neighboring gene STARR-positive B cell enhancer ABC_E4379 Neighboring gene predicted gene, 34207 Neighboring gene leucine rich repeat containing 52 Neighboring gene STARR-seq mESC enhancer starr_02951 Neighboring gene STARR-seq mESC enhancer starr_02952 Neighboring gene retinoid X receptor gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Molyneaux BJ, et al. Neuron, 2015 Jan 21. PMID 25556833, Free PMC Article
  2. Quantitative trait loci for steady-state platelet count in mice. Cheung CC, et al. Mamm Genome, 2004 Oct. PMID 15520881
  3. On the integration of alcohol-related quantitative trait loci and gene expression analyses. Hitzemann R, et al. Alcohol Clin Exp Res, 2004 Oct. PMID 15597075
  4. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
  5. Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. Wu Y, et al. PLoS Genet, 2016 Sep. PMID 27689697, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in prostanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione S-transferase 3, mitochondrial
Names
LTC4 synthase MGST3
glutathione peroxidase MGST3
microsomal GST-3
microsomal GST-III
microsomal glutathione S-transferase III
NP_079845.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025569.2 → NP_079845.1  glutathione S-transferase 3, mitochondrial

    See identical proteins and their annotated locations for NP_079845.1

    Status: VALIDATED

    Source sequence(s)
    AC113970, AK003246
    Consensus CDS
    CCDS15457.1
    UniProtKB/Swiss-Prot
    Q3UXC5, Q9CPU4, Q9D834
    Related
    ENSMUSP00000028005.3, ENSMUST00000028005.3
    Conserved Domains (1) summary
    pfam01124
    Location:11 → 130
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167199535..167221410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029392.1: Suppressed sequence

    Description
    NM_029392.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPU4.1 GenPept UniProtKB/Swiss-Prot:Q9CPU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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