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Cyc1 cytochrome c-1 [ Mus musculus (house mouse) ]

Gene ID: 66445, updated on 5-Mar-2024

Summary

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Official Symbol
Cyc1provided by MGI
Official Full Name
cytochrome c-1provided by MGI
Primary source
MGI:MGI:1913695
See related
Ensembl:ENSMUSG00000022551 AllianceGenome:MGI:1913695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyct1; 2610002H19Rik
Summary
Predicted to enable heme binding activity; metal ion binding activity; and ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c and response to glucagon. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 596.3), duodenum adult (RPKM 388.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 35.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76227711..76230460)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76343513..76346260)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene GPI anchor attachment protein 1 Neighboring gene ribosomal protein S6, pseudogene 1 Neighboring gene SHANK-associated RH domain interacting protein Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons. Yu Z, et al. Mol Neurobiol, 2016 Jul. PMID 26050086
  2. Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c. Hansen TM, et al. Cell Death Differ, 2006 Jul. PMID 16239929
  3. A Bax/Bak-independent mechanism of cytochrome c release. Mizuta T, et al. J Biol Chem, 2007 Jun 1. PMID 17409097
  4. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cipolat S, et al. Cell, 2006 Jul 14. PMID 16839884
  5. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li Y, et al. Nat Commun, 2020 Sep 24. PMID 32973183, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ngb can bind to mitochondrial complex III subunit Cyc1, leading to suppression of oxygen-glucose deprivation -mediated complex III activity.
    Title: Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquinol-cytochrome-c reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to glucagon ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome c1, heme protein, mitochondrial
Names
complex III subunit 4
complex III subunit IV
cytochrome b-c1 complex subunit 4
ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
NP_079843.1
XP_030104554.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025567.3 → NP_079843.1  cytochrome c1, heme protein, mitochondrial

    See identical proteins and their annotated locations for NP_079843.1

    Status: VALIDATED

    Source sequence(s)
    AA738621, AK011288, AW121892
    Consensus CDS
    CCDS27567.1
    UniProtKB/Swiss-Prot
    Q3TDC5, Q3UAN2, Q63ZW4, Q9D0M3, Q9DCG0
    Related
    ENSMUSP00000023210.7, ENSMUST00000023210.8
    Conserved Domains (1) summary
    pfam02167
    Location:96 → 314
    Cytochrom_C1; Cytochrome C1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76227711..76230460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248694.2 → XP_030104554.1  cytochrome c1, heme protein, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam02167
    Location:37 → 253
    Cytochrom_C1; Cytochrome C1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0M3.1 GenPept UniProtKB/Swiss-Prot:Q9D0M3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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