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Magohb mago homolog B, exon junction complex core component [ Mus musculus (house mouse) ]

Gene ID: 66441, updated on 11-Apr-2024

Summary

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Official Symbol
Magohbprovided by MGI
Official Full Name
mago homolog B, exon junction complex core componentprovided by MGI
Primary source
MGI:MGI:1913691
See related
Ensembl:ENSMUSG00000030188 AllianceGenome:MGI:1913691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mago; Magoh; Magoh-rs1; 2010012C16Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to act upstream of or within mRNA processing and mRNA transport. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of exon-exon junction complex and spliceosomal complex. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 7.8), liver E14 (RPKM 7.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 63.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131261351..131270207, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131284389..131293244, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor, subfamily A, member 2 Neighboring gene predicted gene 5582 Neighboring gene STARR-positive B cell enhancer ABC_E9280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131243245-131243354 Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131303559-131303777 Neighboring gene Y box protein 3 Neighboring gene predicted gene, 22362

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter. Ladopoulos V, et al. Mol Cell Biol, 2013 Apr. PMID 23358417, Free PMC Article
  2. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. Singh KK, et al. RNA Biol, 2013 Aug. PMID 23917022, Free PMC Article
  3. Assembly, disassembly and recycling: the dynamics of exon junction complexes. Bono F, et al. RNA Biol, 2011 Jan-Feb. PMID 21289489, Free PMC Article
  4. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. Le Hir H, et al. EMBO J, 2001 Sep 3. PMID 11532962, Free PMC Article
  5. Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode. Gong P, et al. PLoS One, 2014. PMID 24416299, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay
    Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.
  2. Reexpression of KMT2B was sufficient to reinstate an active MagohB promoter.
    Title: The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction subcomplex mago-y14 ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein mago nashi homolog 2
Names
mago nashi protein
mago-nashi homolog B
mago-nashi homolog, proliferation-associated, related sequence 1
protein mago nashi homolog 1-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327860.1 → NP_001314789.1  protein mago nashi homolog 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, resulting in the use of a downstream in-frame translational start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK008200, BE649735
    Consensus CDS
    CCDS85172.1
    UniProtKB/TrEMBL
    G3UZW7
    Related
    ENSMUSP00000134663.2, ENSMUST00000173837.6
    Conserved Domains (1) summary
    cl03715
    Location:1 → 102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

  2. NM_025564.2 → NP_079840.2  protein mago nashi homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_079840.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK008200
    Consensus CDS
    CCDS39670.2
    UniProtKB/TrEMBL
    A0A023T778
    Related
    ENSMUSP00000032307.6, ENSMUST00000032307.12
    Conserved Domains (1) summary
    cd11295
    Location:6 → 148
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    131261351..131270207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152262.1 → XP_036008155.1  protein mago nashi homolog 2 isoform X1

    UniProtKB/TrEMBL
    G3UZW7
    Conserved Domains (1) summary
    cl03715
    Location:1 → 102
    Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQL1.1 GenPept UniProtKB/Swiss-Prot:Q9CQL1

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