U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 66435, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Uggt2provided by MGI
Official Full Name
UDP-glucose glycoprotein glucosyltransferase 2provided by MGI
Primary source
MGI:MGI:1913685
See related
Ensembl:ENSMUSG00000042104 AllianceGenome:MGI:1913685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ugcgl2; 1810064L21Rik; 3110001A05Rik; 3110027P15Rik; A230065J02Rik
Summary
Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and protein N-linked glycosylation via asparagine. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.9), CNS E14 (RPKM 4.9) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Uggt2 in Genome Data Viewer
Location:
14 E4; 14 62.61 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119219177..119337208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118982006..119099796, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4125 Neighboring gene DAZ interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119381910-119382076 Neighboring gene STARR-positive B cell enhancer mm9_chr14:119406665-119406966 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene predicted gene, 16835 Neighboring gene STARR-seq mESC enhancer starr_37667 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene STARR-seq mESC enhancer starr_37668 Neighboring gene STARR-seq mESC enhancer starr_37669 Neighboring gene STARR-seq mESC enhancer starr_37670 Neighboring gene STARR-seq mESC enhancer starr_37671 Neighboring gene tera pseudogene Neighboring gene CD24a antigen pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress. Hung HH, et al. Proc Natl Acad Sci U S A, 2022 Dec 20. PMID 36508673, Free PMC Article
  2. Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT). Prados MB, et al. Biochim Biophys Acta, 2013 Dec. PMID 24140206
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress.
    Title: Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress.
  2. the expression of two UGGT isoforms, UGGT1 and UGGT2 was demonstrated and both isoforms are active mouse hybridoma cells.
    Title: Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT).
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
UDP-glucose:glycoprotein glucosyltransferase 2
Names
UDP-glucose ceramide glucosyltransferase-like 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081252.2 → NP_001074721.2  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_001074721.2

    Status: VALIDATED

    Source sequence(s)
    AC154760
    Consensus CDS
    CCDS37013.2
    UniProtKB/TrEMBL
    E9Q4X2
    Related
    ENSMUSP00000121249.2, ENSMUST00000156203.8
    Conserved Domains (2) summary
    cd06432
    Location:1219 → 1466
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:24 → 1181
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    119219177..119337208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519376.3 → XP_006519439.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

    Conserved Domains (6) summary
    pfam06427
    Location:1083 → 1189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    pfam18400
    Location:36 → 217
    Thioredoxin_12; Thioredoxin-like domain
    pfam18401
    Location:287 → 394
    Thioredoxin_13; Thioredoxin-like domain
    pfam18402
    Location:428 → 676
    Thioredoxin_14; Thioredoxin-like domain
    pfam18403
    Location:700 → 922
    Thioredoxin_15; Thioredoxin-like domain
    pfam18404
    Location:1219 → 1417
    Glyco_transf_24; Glucosyltransferase 24

  2. XM_006519380.5 → XP_006519443.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006519443.1

    Conserved Domains (6) summary
    pfam06427
    Location:1083 → 1189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    pfam18400
    Location:36 → 217
    Thioredoxin_12; Thioredoxin-like domain
    pfam18401
    Location:287 → 394
    Thioredoxin_13; Thioredoxin-like domain
    pfam18402
    Location:428 → 676
    Thioredoxin_14; Thioredoxin-like domain
    pfam18403
    Location:700 → 922
    Thioredoxin_15; Thioredoxin-like domain
    pfam18404
    Location:1219 → 1235
    Glyco_transf_24; Glucosyltransferase 24

RNA

  1. XR_004938436.1 RNA Sequence

  2. XR_003950882.1 RNA Sequence

  3. XR_003950881.1 RNA Sequence

  4. XR_001781137.2 RNA Sequence

  5. XR_004938425.1 RNA Sequence

  6. XR_004938427.1 RNA Sequence

  7. XR_004938428.1 RNA Sequence

  8. XR_003950883.1 RNA Sequence

  9. XR_004938431.1 RNA Sequence

  10. XR_003950885.1 RNA Sequence

  11. XR_004938430.1 RNA Sequence

  12. XR_004938433.1 RNA Sequence

  13. XR_004938434.1 RNA Sequence

  14. XR_004938435.1 RNA Sequence

  15. XR_003950884.1 RNA Sequence

  16. XR_003950888.1 RNA Sequence

  17. XR_003950889.1 RNA Sequence

  18. XR_004938429.1 RNA Sequence

  19. XR_003950887.1 RNA Sequence

  20. XR_004938438.1 RNA Sequence

  21. XR_004938439.1 RNA Sequence

  22. XR_003950891.2 RNA Sequence

  23. XR_003950890.1 RNA Sequence

  24. XR_003950892.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025561.1: Suppressed sequence

    Description
    NM_025561.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous