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Arrdc4 arrestin domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 66412, updated on 11-Apr-2024

Summary

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Official Symbol
Arrdc4provided by MGI
Official Full Name
arrestin domain containing 4provided by MGI
Primary source
MGI:MGI:1913662
See related
Ensembl:ENSMUSG00000042659 AllianceGenome:MGI:1913662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410003C09Rik
Summary
Enables ubiquitin ligase-substrate adaptor activity. Involved in extracellular vesicle biogenesis; protein transport; and protein ubiquitination. Located in extracellular vesicle and plasma membrane. Orthologous to human ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.0), colon adult (RPKM 8.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 C; 7 37.81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (68386742..68398986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (68736994..68749238, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34549 Neighboring gene STARR-seq mESC enhancer starr_19116 Neighboring gene tetraspanin 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19117 Neighboring gene STARR-seq mESC enhancer starr_19119 Neighboring gene STARR-seq mESC enhancer starr_19120 Neighboring gene STARR-seq mESC enhancer starr_19121 Neighboring gene predicted gene, 34612 Neighboring gene predicted gene, 34664 Neighboring gene STARR-seq mESC enhancer starr_19123

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart. Nakayama Y, et al. Circ Res, 2022 Sep 2. PMID 35950500, Free PMC Article
  2. Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation. Foot NJ, et al. J Extracell Vesicles, 2021 Jun. PMID 34188787, Free PMC Article
  3. TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4. Wang H, et al. Cell Death Dis, 2021 Dec 17. PMID 34916487, Free PMC Article
  4. The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange. Patwari P, et al. J Biol Chem, 2006 Aug 4. PMID 16766796, Free PMC Article
  5. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. Patwari P, et al. J Biol Chem, 2009 Sep 11. PMID 19605364, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
    Title: Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
  2. An insulin-regulated arrestin domain protein controls hepatic glucagon action.
    Title: An insulin-regulated arrestin domain protein controls hepatic glucagon action.
  3. Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
    Title: Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
  4. TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
    Title: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
  5. Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
    Title: Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
  6. Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins
    Title: Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in extracellular vesicle biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arrestin domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042592.2 → NP_001036057.1  arrestin domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001036057.1

    Status: VALIDATED

    Source sequence(s)
    AK037198, AV245884, BY738896
    Consensus CDS
    CCDS39985.1
    UniProtKB/Swiss-Prot
    A0A0B4J1F4, Q8VD69
    UniProtKB/TrEMBL
    Q0GJK1
    Related
    ENSMUSP00000044578.8, ENSMUST00000048068.15
    Conserved Domains (2) summary
    smart01017
    Location:188 → 315
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19 → 166
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  2. NM_025549.3 → NP_079825.2  arrestin domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_079825.2

    Status: VALIDATED

    Source sequence(s)
    AK010352, AK037198, BY738896
    Consensus CDS
    CCDS52272.1
    UniProtKB/TrEMBL
    Q9D6S6
    Related
    ENSMUSP00000112962.2, ENSMUST00000118110.3
    Conserved Domains (2) summary
    smart01017
    Location:188 → 292
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:23 → 166
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    68386742..68398986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4J1F4.1 GenPept UniProtKB/Swiss-Prot:A0A0B4J1F4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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