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Tbcb tubulin folding cofactor B [ Mus musculus (house mouse) ]

Gene ID: 66411, updated on 5-Mar-2024

Summary

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Official Symbol
Tbcbprovided by MGI
Official Full Name
tubulin folding cofactor Bprovided by MGI
Primary source
MGI:MGI:1913661
See related
Ensembl:ENSMUSG00000006095 AllianceGenome:MGI:1913661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CG22; CKAPI; Ckap1; 2410007D12Rik
Summary
Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 59.9), CNS E14 (RPKM 49.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tbcb in Genome Data Viewer
Location:
7 B1; 7 17.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29923554..29931622, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30224129..30232197, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4914 Neighboring gene predicted gene, 53356 Neighboring gene STARR-seq mESC enhancer starr_18511 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene STARR-positive B cell enhancer ABC_E6531 Neighboring gene STARR-positive B cell enhancer ABC_E6532 Neighboring gene calpain, small subunit 1 Neighboring gene STARR-seq mESC enhancer starr_18512 Neighboring gene STARR-positive B cell enhancer ABC_E4915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide I Neighboring gene ovo like zinc finger 3 Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tubulin cofactor B plays a role in the neuronal growth cone. Lopez-Fanarraga M, et al. J Neurochem, 2007 Mar. PMID 17217416
  2. Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. Kortazar D, et al. Exp Cell Res, 2007 Feb 1. PMID 17184771
  3. Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued). Kuh GF, et al. Cell Tissue Res, 2012 Oct. PMID 22777741
  4. Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice. Ganay T, et al. Mol Neurodegener, 2011 Apr 12. PMID 21486449, Free PMC Article
  5. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Wen HL, et al. Hum Mol Genet, 2010 May 1. PMID 20176735

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulin-folding cofactor B
Names
cytoskeleton-associated protein 1
cytoskeleton-associated protein CKAPI
tubulin-specific chaperone B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360648.1 → NP_001347577.1  tubulin-folding cofactor B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC149067
    Conserved Domains (2) summary
    pfam01302
    Location:110 → 178
    CAP_GLY; CAP-Gly domain
    cl00155
    Location:1 → 41
    UBQ; Ubiquitin-like proteins

  2. NM_001360649.1 → NP_001347578.1  tubulin-folding cofactor B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA718358, AC149067
    Conserved Domains (1) summary
    cd01789
    Location:10 → 92
    Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B

  3. NM_025548.4 → NP_079824.2  tubulin-folding cofactor B isoform 1

    See identical proteins and their annotated locations for NP_079824.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC149067
    Consensus CDS
    CCDS21083.1
    UniProtKB/Swiss-Prot
    Q9CWR6, Q9D1E6, Q9DCZ6
    Related
    ENSMUSP00000006254.6, ENSMUST00000006254.6
    Conserved Domains (2) summary
    cd01789
    Location:10 → 92
    Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
    pfam01302
    Location:162 → 229
    CAP_GLY; CAP-Gly domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29923554..29931622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1E6.2 GenPept UniProtKB/Swiss-Prot:Q9D1E6

Gene LinkOut

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