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Mrps15 mitochondrial ribosomal protein S15 [ Mus musculus (house mouse) ]

Gene ID: 66407, updated on 5-Mar-2024

Summary

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Official Symbol
Mrps15provided by MGI
Official Full Name
mitochondrial ribosomal protein S15provided by MGI
Primary source
MGI:MGI:1913657
See related
Ensembl:ENSMUSG00000028861 AllianceGenome:MGI:1913657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mprs15; 1500003E24Rik; 2410002B11Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrial ribosome. Is expressed in several structures, including early conceptus; gonad; liver; nervous system; and submandibular gland primordium. Orthologous to human MRPS15 (mitochondrial ribosomal protein S15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 94.7), duodenum adult (RPKM 79.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrps15 in Genome Data Viewer
Location:
4 D2.2; 4 59.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125940721..125949329)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126046928..126055536)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610028E06 gene Neighboring gene STARR-positive B cell enhancer ABC_E6216 Neighboring gene STARR-seq mESC enhancer starr_11388 Neighboring gene predicted gene, 32908 Neighboring gene colony stimulating factor 3 receptor Neighboring gene STARR-positive B cell enhancer ABC_E2121 Neighboring gene STARR-positive B cell enhancer ABC_E3512 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene U7 snRNP-specific Sm-like protein LSM10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes. Shi Z, et al. FASEB J, 2019 Nov. PMID 31487196
  2. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694
  3. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
  5. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS15m
Names
28S ribosomal protein S15, mitochondrial
MRP-S15
S15mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025544.2 → NP_079820.2  small ribosomal subunit protein uS15m precursor

    See identical proteins and their annotated locations for NP_079820.2

    Status: VALIDATED

    Source sequence(s)
    AK010330, AK050396, CF582282
    Consensus CDS
    CCDS18641.1
    UniProtKB/Swiss-Prot
    Q7TMG9, Q8C7F1, Q9CVE0, Q9CWX1, Q9DC71
    Related
    ENSMUSP00000030675.8, ENSMUST00000030675.8
    Conserved Domains (1) summary
    pfam00312
    Location:113 → 187
    Ribosomal_S15; Ribosomal protein S15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125940721..125949329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DC71.2 GenPept UniProtKB/Swiss-Prot:Q9DC71

Gene LinkOut

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