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Sac3d1 SAC3 domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66406, updated on 5-Mar-2024

Summary

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Official Symbol
Sac3d1provided by MGI
Official Full Name
SAC3 domain containing 1provided by MGI
Primary source
MGI:MGI:1913656
See related
Ensembl:ENSMUSG00000024790 AllianceGenome:MGI:1913656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
shd1; 2410004C24Rik
Summary
Acts upstream of or within microtubule cytoskeleton organization; negative regulation of receptor signaling pathway via JAK-STAT; and regulation of immune response. Located in centrosome; nucleus; and spindle. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SAC3D1 (SAC3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 50.3), adrenal adult (RPKM 46.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6166025..6168689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6116004..6118586, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 550 Neighboring gene N-acetylated alpha-linked acidic dipeptidase-like 1 Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene sorting nexin 15 Neighboring gene STARR-positive B cell enhancer ABC_E11014 Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene ADP-ribosylation factor-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells. Khuda SE, et al. J Biol Chem, 2004 Oct 29. PMID 15322101
  2. SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription. Nakajima H, et al. Blood, 2009 Jan 29. PMID 18838617
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SHD1 is a novel cytokine-inducible negative feedback regulator of STAT5a.
    Title: SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SAC3 domain-containing protein 1
Names
SAC3 homology domain-containing protein 1
Sac3 homology domain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133678.3 → NP_598439.3  SAC3 domain-containing protein 1

    See identical proteins and their annotated locations for NP_598439.3

    Status: VALIDATED

    Source sequence(s)
    AK075930, BI134670
    Consensus CDS
    CCDS37896.1
    UniProtKB/Swiss-Prot
    A6H687, B7ZMU9, Q8BVY1, Q9QXE1
    UniProtKB/TrEMBL
    G5E8Q7
    Related
    ENSMUSP00000109161.2, ENSMUST00000113533.3
    Conserved Domains (1) summary
    pfam03399
    Location:150 → 356
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6166025..6168689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161651.1 → XP_036017544.1  SAC3 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cl24019
    Location:81 → 266
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H687.1 GenPept UniProtKB/Swiss-Prot:A6H687

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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