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Alkbh7 alkB homolog 7 [ Mus musculus (house mouse) ]

Gene ID: 66400, updated on 5-Mar-2024

Summary

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Official Symbol
Alkbh7provided by MGI
Official Full Name
alkB homolog 7provided by MGI
Primary source
MGI:MGI:1913650
See related
Ensembl:ENSMUSG00000002661 AllianceGenome:MGI:1913650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abh7; Spata11; 2310045B01Rik; 2510008E23Rik
Summary
Predicted to enable dioxygenase activity and metal ion binding activity. Involved in fatty acid metabolic process and regulation of lipid storage. Located in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 71.0), ovary adult (RPKM 30.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57304339..57306340)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56997339..56999340)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33509 Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E491 Neighboring gene persephin Neighboring gene general transcription factor IIF, polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E492 Neighboring gene adenylate kinase 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ALKBH7 mediates necrosis via rewiring of glyoxal metabolism. Kulkarni CA, et al. Elife, 2020 Aug 14. PMID 32795389, Free PMC Article
  2. Deletion of mouse Alkbh7 leads to obesity. Solberg A, et al. J Mol Cell Biol, 2013 Jun. PMID 23572141
  3. ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Jordan JJ, et al. Cell Death Dis, 2017 Jul 20. PMID 28726787, Free PMC Article
  4. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. Lee DH, et al. J Biol Chem, 2005 Nov 25. PMID 16174769
  5. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables 2-oxoglutarate-dependent dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
Names
alkB, alkylation repair homolog 7
alkylated DNA repair protein alkB homolog 7
probable alpha-ketoglutarate-dependent dioxygenase ABH7
spermatogenesis associated 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025538.3 → NP_079814.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_079814.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073683, AK009812, AK010930
    Consensus CDS
    CCDS28921.1
    UniProtKB/Swiss-Prot
    Q8K1H3, Q9CY41, Q9D6Z0, Q9D942
    Related
    ENSMUSP00000002737.7, ENSMUST00000002737.7
    Conserved Domains (1) summary
    cl21496
    Location:33 → 200
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  2. NM_027372.1 → NP_081648.1  alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_081648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC073683, AK010930
    Consensus CDS
    CCDS57105.1
    UniProtKB/Swiss-Prot
    Q9D6Z0
    Related
    ENSMUSP00000073775.8, ENSMUST00000074141.14
    Conserved Domains (1) summary
    cl21496
    Location:73 → 139
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57304339..57306340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D6Z0.1 GenPept UniProtKB/Swiss-Prot:Q9D6Z0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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