Tsfm Ts translation elongation factor, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsfmprovided by MGI
Official Full Name: Ts translation elongation factor, mitochondrialprovided by MGI
Primary source: MGI:MGI:1913649
See related: Ensembl:ENSMUSG00000040521 AllianceGenome:MGI:1913649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EF-TS; EF-Tsmt; 2310050B20Rik; 9430024O13Rik
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 24.4), ovary adult (RPKM 16.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (126858201..126866683, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127022332..127030814, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: elongation factor Ts, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025537.3 → NP_079813.1 elongation factor Ts, mitochondrial precursor

See identical proteins and their annotated locations for NP_079813.1

Status: VALIDATED

Source sequence(s)

AC134329

Consensus CDS

CCDS24222.1

UniProtKB/Swiss-Prot

Q3TFF5, Q9CZR8

UniProtKB/TrEMBL

Q3TA37

Related

ENSMUSP00000042134.5, ENSMUST00000040560.11

Conserved Domains (3) summary

PRK09377
Location:42 → 316

tsf; elongation factor Ts; Provisional

cd14275
Location:47 → 83

UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes

pfam00889
Location:115 → 316

EF_TS; Elongation factor TS