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Zfand1 zinc finger, AN1-type domain 1 [ Mus musculus (house mouse) ]

Gene ID: 66361, updated on 11-Apr-2024

Summary

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Official Symbol
Zfand1provided by MGI
Official Full Name
zinc finger, AN1-type domain 1provided by MGI
Primary source
MGI:MGI:1913611
See related
Ensembl:ENSMUSG00000039795 AllianceGenome:MGI:1913611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310008M20Rik
Summary
Predicted to enable proteasome binding activity. Predicted to be involved in cellular response to arsenite ion; positive regulation of intracellular protein transport; and stress granule disassembly. Predicted to be active in cytoplasmic stress granule. Is expressed in bladder; male associated reproductive structure; testis; and urethra of male. Orthologous to human ZFAND1 (zinc finger AN1-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.1), CNS E11.5 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A1; 3 2.62 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10405013..10416383, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10339956..10351334, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene inositol (myo)-1(or 4)-monophosphatase 1 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E7900 Neighboring gene STARR-positive B cell enhancer mm9_chr3:10351257-10351557 Neighboring gene STARR-seq mESC enhancer starr_06944 Neighboring gene charged multivesicular body protein 4C Neighboring gene sorting nexin 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. Sá-Moura B, et al. J Biol Chem, 2013 Nov 22. PMID 24121501, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC107161

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to arsenite ion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress granule disassembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 1
Names
zinc finger AN1-type-containing protein 1
NP_001317942.1
NP_001317943.1
NP_001317944.1
NP_001385989.1
NP_001385990.1
NP_001385991.1
NP_001385992.1
NP_079788.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331013.2 → NP_001317942.1  AN1-type zinc finger protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123726
    Consensus CDS
    CCDS89614.1
    UniProtKB/TrEMBL
    D3Z7G5
    Related
    ENSMUSP00000104014.2, ENSMUST00000108377.8

  2. NM_001331014.2 → NP_001317943.1  AN1-type zinc finger protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123726
    UniProtKB/TrEMBL
    F7CFT1
    Conserved Domains (1) summary
    pfam01428
    Location:41 → 77
    zf-AN1; AN1-like Zinc finger

  3. NM_001331015.2 → NP_001317944.1  AN1-type zinc finger protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123726
    UniProtKB/Swiss-Prot
    Q8BFR6
    Conserved Domains (1) summary
    cl21456
    Location:13 → 84
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  4. NM_001399060.1 → NP_001385989.1  AN1-type zinc finger protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123726
    Conserved Domains (1) summary
    pfam01428
    Location:74 → 110
    zf-AN1; AN1-like Zinc finger

  5. NM_001399061.1 → NP_001385990.1  AN1-type zinc finger protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123726

  6. NM_001399062.1 → NP_001385991.1  AN1-type zinc finger protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123726
    Conserved Domains (1) summary
    pfam01428
    Location:41 → 77
    zf-AN1; AN1-like Zinc finger

  7. NM_001399063.1 → NP_001385992.1  AN1-type zinc finger protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123726
    Conserved Domains (1) summary
    pfam01428
    Location:41 → 77
    zf-AN1; AN1-like Zinc finger

  8. NM_025512.4 → NP_079788.2  AN1-type zinc finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_079788.2

    Status: VALIDATED

    Source sequence(s)
    AC123726
    Consensus CDS
    CCDS17242.1
    UniProtKB/Swiss-Prot
    Q8BFR6, Q8R3Y6, Q9D7H5
    UniProtKB/TrEMBL
    F7CFT1
    Related
    ENSMUSP00000037459.6, ENSMUST00000037839.12
    Conserved Domains (2) summary
    pfam01428
    Location:10 → 46
    zf-AN1; AN1-like Zinc finger
    cl21456
    Location:120 → 191
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    10405013..10416383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFR6.1 GenPept UniProtKB/Swiss-Prot:Q8BFR6

Gene LinkOut

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