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Cox20 cytochrome c oxidase assembly protein 20 [ Mus musculus (house mouse) ]

Gene ID: 66359, updated on 5-Mar-2024

Summary

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Official Symbol
Cox20provided by MGI
Official Full Name
cytochrome c oxidase assembly protein 20provided by MGI
Primary source
MGI:MGI:1913609
See related
Ensembl:ENSMUSG00000026500 AllianceGenome:MGI:1913609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam36a; 2310005N03Rik
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX20 (cytochrome c oxidase assembly factor COX20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 18.9), CNS E11.5 (RPKM 17.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H4; 1 83.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (178146379..178150258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (178318095..178322693)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03142 Neighboring gene predicted gene, 46174 Neighboring gene STARR-seq mESC enhancer starr_03146 Neighboring gene RIKEN cDNA B230369F24 gene Neighboring gene STARR-seq mESC enhancer starr_03147 Neighboring gene STARR-seq mESC enhancer starr_03148 Neighboring gene STARR-seq mESC enhancer starr_03149 Neighboring gene heterogeneous nuclear ribonucleoprotein U Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:180299062-180299171 Neighboring gene STARR-positive B cell enhancer ABC_E10066 Neighboring gene predicted gene, 24919 Neighboring gene STARR-seq mESC enhancer starr_03153 Neighboring gene EF-hand calcium binding domain 2 Neighboring gene predicted gene, 53484

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome c oxidase assembly protein COX20, mitochondrial
Names
COX20 Cox2 chaperone
cytochrome c oxidase protein 20 homolog
family with sequence similarity 36, member A
protein FAM36A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025511.2 → NP_079787.1  cytochrome c oxidase assembly protein COX20, mitochondrial

    See identical proteins and their annotated locations for NP_079787.1

    Status: VALIDATED

    Source sequence(s)
    AK009178, BY779933
    Consensus CDS
    CCDS15556.1
    UniProtKB/Swiss-Prot
    Q8BT52, Q9D7J4
    Related
    ENSMUSP00000027781.7, ENSMUST00000027781.7
    Conserved Domains (1) summary
    pfam12597
    Location:13 → 97
    DUF3767; Protein of unknown function (DUF3767)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    178146379..178150258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321962.3 → XP_017177451.1  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X2

  2. XM_036152821.1 → XP_036008714.1  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam12597
    Location:36 → 118
    DUF3767; Protein of unknown function (DUF3767)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7J4.1 GenPept UniProtKB/Swiss-Prot:Q9D7J4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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