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Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [ Mus musculus (house mouse) ]

Gene ID: 66358, updated on 11-Apr-2024

Summary

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Official Symbol
Adprmprovided by MGI
Official Full Name
ADP-ribose/CDP-alcohol diphosphatase, manganese dependentprovided by MGI
Primary source
MGI:MGI:1913608
See related
Ensembl:ENSMUSG00000020910 AllianceGenome:MGI:1913608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDS006; 2310004I24Rik
Summary
Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Orthologous to human ADPRM (ADP-ribose/CDP-alcohol diphosphatase, manganese dependent). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 40.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66928706..66943481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67037880..67052631, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12299 Neighboring gene STARR-seq mESC enhancer starr_29788 Neighboring gene STARR-seq mESC enhancer starr_29789 Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene transmembrane protein 220 Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene myosin, heavy polypeptide 3, skeletal muscle, embryonic Neighboring gene microRNA 6923 Neighboring gene RIKEN cDNA 2310065F04 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. Canales J, et al. Biochem J, 2008 Jul 1. PMID 18352857
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure and function of Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase in immune tissues are reported.
    Title: Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-ribose diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CDP-glycerol diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Names
ADP-ribose/CDP-alcohol pyrophosphatase
ADPRibase-Mn
CDP-choline phosphohydrolase
NP_079786.2
XP_006534003.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025510.3 → NP_079786.2  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

    See identical proteins and their annotated locations for NP_079786.2

    Status: VALIDATED

    Source sequence(s)
    AK145941, BY118851
    Consensus CDS
    CCDS48820.1
    UniProtKB/Swiss-Prot
    Q5SUD1, Q99KS6, Q9D7K9
    Related
    ENSMUSP00000112064.2, ENSMUST00000116363.2
    Conserved Domains (1) summary
    cd07396
    Location:18 → 322
    MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    66928706..66943481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533940.4 → XP_006534003.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1

    See identical proteins and their annotated locations for XP_006534003.1

    UniProtKB/Swiss-Prot
    Q5SUD1, Q99KS6, Q9D7K9
    Conserved Domains (1) summary
    cd07396
    Location:18 → 322
    MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KS6.1 GenPept UniProtKB/Swiss-Prot:Q99KS6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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