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Dmac2 distal membrane arm assembly complex 2 [ Mus musculus (house mouse) ]

Gene ID: 66349, updated on 5-Mar-2024

Summary

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Official Symbol
Dmac2provided by MGI
Official Full Name
distal membrane arm assembly complex 2provided by MGI
Primary source
MGI:MGI:1913599
See related
Ensembl:ENSMUSG00000057229 AllianceGenome:MGI:1913599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5sl; 2310004L02Rik; C030044E10Rik
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Orthologous to human DMAC2 (distal membrane arm assembly component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 27.8), kidney adult (RPKM 26.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 13.93 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25318839..25324975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25619414..25625550)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9286 Neighboring gene glutamate rich 4 Neighboring gene predicted gene, 38969 Neighboring gene predicted gene, 57782 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E8156 Neighboring gene STARR-positive B cell enhancer ABC_E10430 Neighboring gene STARR-seq mESC enhancer starr_18309

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
distal membrane-arm assembly complex protein 2
Names
ATP synthase subunit s-like protein
ATP5S-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290487.1 → NP_001277416.1  distal membrane-arm assembly complex protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001277416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC162614, AK009150
    Consensus CDS
    CCDS71917.1
    UniProtKB/Swiss-Prot
    Q9D7K5
    UniProtKB/TrEMBL
    Q9DCX4
    Related
    ENSMUSP00000076563.6, ENSMUST00000077338.12
    Conserved Domains (2) summary
    cd09293
    Location:149 → 221
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:151 → 176
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_025504.4 → NP_079780.2  distal membrane-arm assembly complex protein 2 isoform 2

    See identical proteins and their annotated locations for NP_079780.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC162614
    Consensus CDS
    CCDS20988.1
    UniProtKB/TrEMBL
    Q8CA44, Q9DCX4
    Related
    ENSMUSP00000083115.4, ENSMUST00000085953.5
    Conserved Domains (2) summary
    cd09293
    Location:148 → 220
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:150 → 175
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25318839..25324975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7K5.1 GenPept UniProtKB/Swiss-Prot:Q9D7K5

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