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Cenpp centromere protein P [ Mus musculus (house mouse) ]

Gene ID: 66336, updated on 5-Mar-2024

Summary

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Official Symbol
Cenppprovided by MGI
Official Full Name
centromere protein Pprovided by MGI
Primary source
MGI:MGI:1913586
See related
Ensembl:ENSMUSG00000021391 AllianceGenome:MGI:1913586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700022C02Rik; 4921518G09Rik
Summary
Predicted to be involved in CENP-A containing chromatin assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CENPP (centromere protein P). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 2.2), limb E14.5 (RPKM 2.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 25.27 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49617501..49806457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49464025..49652950, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene BICD cargo adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_34478 Neighboring gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene asporin Neighboring gene STARR-seq mESC enhancer starr_34480 Neighboring gene osteomodulin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E8527 Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene isoleucyl-tRNA synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein P
Names
CENP-P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025495.4 → NP_079771.1  centromere protein P

    See identical proteins and their annotated locations for NP_079771.1

    Status: VALIDATED

    Source sequence(s)
    AC123954, AC160978
    Consensus CDS
    CCDS26501.1
    UniProtKB/Swiss-Prot
    Q52KM2, Q8C647, Q9CVW9, Q9CZ92, Q9D5U7
    UniProtKB/TrEMBL
    B2RVI6
    Related
    ENSMUSP00000021818.8, ENSMUST00000021818.9
    Conserved Domains (1) summary
    pfam13096
    Location:102 → 278
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49617501..49806457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247350.2 → XP_030103210.1  centromere protein P isoform X5

    Conserved Domains (1) summary
    pfam13096
    Location:1 → 138
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

  2. XM_011244405.4 → XP_011242707.1  centromere protein P isoform X2

    Conserved Domains (1) summary
    pfam13096
    Location:102 → 187
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

  3. XM_036158109.1 → XP_036014002.1  centromere protein P isoform X3

    Conserved Domains (1) summary
    pfam13096
    Location:102 → 187
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

  4. XM_036158108.1 → XP_036014001.1  centromere protein P isoform X3

    Conserved Domains (1) summary
    pfam13096
    Location:102 → 187
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

  5. XM_036158107.1 → XP_036014000.1  centromere protein P isoform X1

    Conserved Domains (1) summary
    pfam13096
    Location:102 → 187
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

  6. XM_011244407.4 → XP_011242709.1  centromere protein P isoform X4

    Conserved Domains (1) summary
    pfam13096
    Location:102 → 187
    CENP-P; CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P

RNA

  1. XR_004938050.1 RNA Sequence

  2. XR_003950462.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ92.1 GenPept UniProtKB/Swiss-Prot:Q9CZ92

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