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Skic8 SKI8 subunit of superkiller complex [ Mus musculus (house mouse) ]

Gene ID: 66317, updated on 5-Mar-2024

Summary

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Official Symbol
Skic8provided by MGI
Official Full Name
SKI8 subunit of superkiller complexprovided by MGI
Primary source
MGI:MGI:1917493
See related
Ensembl:ENSMUSG00000061559 AllianceGenome:MGI:1917493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ski8; REC14; Wdr61; 2700038L12Rik; 2810418I05Rik
Summary
Predicted to be involved in several processes, including histone H3-K4 trimethylation; positive regulation of histone methylation; and transcription elongation from RNA polymerase II promoter. Predicted to act upstream of or within Wnt signaling pathway. Part of Cdc73/Paf1 complex. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human WDR61 (WD repeat domain 61). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 61.0), bladder adult (RPKM 36.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 29.73 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54624437..54641833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54717153..54734549, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46113 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene microRNA 5710 Neighboring gene STARR-positive B cell enhancer ABC_E3830 Neighboring gene cellular retinoic acid binding protein I Neighboring gene STARR-seq mESC enhancer starr_24173 Neighboring gene STARR-seq mESC enhancer starr_24174 Neighboring gene RAB7, member RAS oncogene family, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Strikoudis A, et al. Nat Cell Biol, 2016 Nov. PMID 27749823, Free PMC Article
  2. Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. Cai Y, et al. BMC Pulm Med, 2015 Jul 16. PMID 26178733, Free PMC Article
  3. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Ding L, et al. Cell Stem Cell, 2009 May 8. PMID 19345177
  4. WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Pashkova N, et al. Mol Cell, 2010 Nov 12. PMID 21070969, Free PMC Article
  5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Higa LA, et al. Nat Cell Biol, 2006 Nov. PMID 17041588

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cdc73/Paf1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Cdc73/Paf1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ski complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
superkiller complex protein 8
Names
SKI8 subunit of superkiller complex protein
WD repeat domain 61
WD repeat-containing protein 61
meiotic recombination protein REC14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025375.2 → NP_001020546.1  superkiller complex protein 8 isoform a

    See identical proteins and their annotated locations for NP_001020546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC159892, AK012342, AK167706
    Consensus CDS
    CCDS23194.1
    UniProtKB/Swiss-Prot
    Q3U562, Q9CZP1, Q9ERF3
    UniProtKB/TrEMBL
    A0MNP4
    Related
    ENSMUSP00000113560.2, ENSMUST00000121204.8
    Conserved Domains (2) summary
    cd00200
    Location:13 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:110 → 146
    7WD40; WD40 repeat [structural motif]

  2. NM_001025376.2 → NP_001020547.1  superkiller complex protein 8 isoform b

    See identical proteins and their annotated locations for NP_001020547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at an internal exon compared to variant 1. This difference results in predicted translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded protein (isoform b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC159892, AK010283
    Consensus CDS
    CCDS59747.1
    UniProtKB/TrEMBL
    D6RDC7, Q9CWZ4
    Related
    ENSMUSP00000123077.3, ENSMUST00000130368.8
    Conserved Domains (2) summary
    cd00200
    Location:12 → 204
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:12 → 48
    7WD40; WD40 repeat [structural motif]

  3. NM_023191.3 → NP_075680.1  superkiller complex protein 8 isoform a

    See identical proteins and their annotated locations for NP_075680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC159892, AK013114
    Consensus CDS
    CCDS23194.1
    UniProtKB/Swiss-Prot
    Q3U562, Q9CZP1, Q9ERF3
    UniProtKB/TrEMBL
    A0MNP4
    Related
    ENSMUSP00000056359.7, ENSMUST00000051822.13
    Conserved Domains (2) summary
    cd00200
    Location:13 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:110 → 146
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54624437..54641833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242785.2 → XP_011241087.1  superkiller complex protein 8 isoform X2

    See identical proteins and their annotated locations for XP_011241087.1

    UniProtKB/TrEMBL
    D6RDC7, Q9CWZ4
    Conserved Domains (2) summary
    cd00200
    Location:12 → 204
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:12 → 48
    7WD40; WD40 repeat [structural motif]

  2. XM_036155174.1 → XP_036011067.1  superkiller complex protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q3U562, Q9CZP1, Q9ERF3
    UniProtKB/TrEMBL
    A0MNP4
    Conserved Domains (2) summary
    cd00200
    Location:13 → 302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:110 → 146
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERF3.1 GenPept UniProtKB/Swiss-Prot:Q9ERF3

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