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Klf15 Kruppel-like transcription factor 15 [ Mus musculus (house mouse) ]

Gene ID: 66277, updated on 21-Apr-2024

Summary

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Official Symbol
Klf15provided by MGI
Official Full Name
Kruppel-like transcription factor 15provided by MGI
Primary source
MGI:MGI:1929988
See related
Ensembl:ENSMUSG00000030087 AllianceGenome:MGI:1929988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CKLF; KKLF; hlb444; 1810013I09Rik
Summary
Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in cardiac muscle hypertrophy in response to stress; glomerular visceral epithelial cell differentiation; and negative regulation of peptidyl-lysine acetylation. Acts upstream of or within several processes, including cellular glucose homeostasis; positive regulation of glucose import; and response to insulin. Located in nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; metanephros; and nose. Used to study aortic aneurysm. Orthologous to human KLF15 (Kruppel like factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 36.3), kidney adult (RPKM 26.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6; 6 D1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90437785..90468785)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90461043..90491803)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100 Neighboring gene predicted gene, 53295 Neighboring gene STARR-seq mESC enhancer starr_16619 Neighboring gene STARR-seq mESC enhancer starr_16625 Neighboring gene STARR-seq mESC enhancer starr_16627 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene STARR-positive B cell enhancer ABC_E8115 Neighboring gene predicted gene 15756 Neighboring gene solute carrier family 41, member 3 Neighboring gene predicted gene, 53296

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands. Fan L, et al. iScience, 2022 Nov 18. PMID 36304102, Free PMC Article
  2. Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARγ to Ameliorate Obesity. Hu Y, et al. Mol Nutr Food Res, 2022 Nov. PMID 35983694
  3. KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice. Massopust R, et al. Neurobiol Dis, 2022 Jan. PMID 34902552, Free PMC Article
  4. KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice. Tian Y, et al. Toxicol Appl Pharmacol, 2021 Sep 15. PMID 34310909
  5. Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis. Fan L, et al. J Clin Invest, 2021 Feb 15. PMID 33586679, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
    Title: Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
  2. Kruppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.
    Title: Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.
  3. Kruppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
    Title: Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
  4. The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5.
    Title: The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5.
  5. Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
    Title: Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
  6. Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARgamma to Ameliorate Obesity.
    Title: Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARγ to Ameliorate Obesity.
  7. Transcription factors KLF15 and PPARdelta cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.
    Title: Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.
  8. CTRP12 alleviates cardiomyocyte ischemiareperfusion injury via regulation of KLF15.
    Title: CTRP12 alleviates cardiomyocyte ischemia‑reperfusion injury via regulation of KLF15.
  9. A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.
    Title: A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.
  10. KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice.
    Title: KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular glucose homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of glucose import IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to insulin IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Krueppel-like factor 15
Names
Kruppel-like factor 15
cardiovascular Krueppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355668.1 → NP_001342597.1  Krueppel-like factor 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163346
    Conserved Domains (2) summary
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 344
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_023184.4 → NP_075673.1  Krueppel-like factor 15 isoform 1

    See identical proteins and their annotated locations for NP_075673.1

    Status: VALIDATED

    Source sequence(s)
    AC163346
    Consensus CDS
    CCDS20360.1
    UniProtKB/Swiss-Prot
    Q3UQB0, Q9EPW2
    Related
    ENSMUSP00000032174.6, ENSMUST00000032174.12
    Conserved Domains (4) summary
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 344
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:366 → 391
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:322 → 401
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    90437785..90468785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255539.2 → XP_030111399.1  Krueppel-like factor 15 isoform X4

    Conserved Domains (3) summary
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 344
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:336 → 358
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006506472.4 → XP_006506535.1  Krueppel-like factor 15 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:427 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:425 → 449
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:441 → 463
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011241425.3 → XP_011239727.1  Krueppel-like factor 15 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:427 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:425 → 449
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:441 → 463
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006506471.4 → XP_006506534.1  Krueppel-like factor 15 isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:423 → 505
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:427 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:471 → 496
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_003956249.2 RNA Sequence

  2. XR_003956248.2 RNA Sequence

  3. XR_377485.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPW2.1 GenPept UniProtKB/Swiss-Prot:Q9EPW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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