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Ing5 inhibitor of growth family, member 5 [ Mus musculus (house mouse) ]

Gene ID: 66262, updated on 10-Mar-2024

Summary

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Official Symbol
Ing5provided by MGI
Official Full Name
inhibitor of growth family, member 5provided by MGI
Primary source
MGI:MGI:1922816
See related
Ensembl:ENSMUSG00000026283 AllianceGenome:MGI:1922816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700001C14Rik; 1700027H23Rik; 1810018M11Rik
Summary
Enables chromatin binding activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of apoptotic signaling pathway. Predicted to be located in chromosome. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in 1st branchial arch maxillary component; early conceptus; eye; and genitourinary system. Orthologous to human ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.0), CNS E11.5 (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 47.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93731648..93749823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93803926..93822101)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95698432-95698719 Neighboring gene STARR-positive B cell enhancer ABC_E4338 Neighboring gene deoxythymidylate kinase Neighboring gene predicted gene, 22089 Neighboring gene STARR-positive B cell enhancer ABC_E7734 Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene STARR-seq mESC enhancer starr_01736

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver. Mah SYY, et al. Front Immunol, 2023. PMID 37275850, Free PMC Article
  2. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway. Zhang GJ, et al. Biochem Biophys Res Commun, 2018 Feb 5. PMID 29326045
  3. Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells. Wang C, et al. Differentiation, 2020 Mar-Apr. PMID 31838455
  4. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One, 2011. PMID 21750715, Free PMC Article
  5. MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Voss AK, et al. Dev Cell, 2012 Sep 11. PMID 22921202, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
    Title: ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.
  2. The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
    Title: The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver.
  3. Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.
    Title: Expression analysis of microRNAs and mRNAs in myofibroblast differentiation of lung resident mesenchymal stem cells.
  4. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway.
    Title: ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin disassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fibroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025454.2 → NP_079730.1  inhibitor of growth protein 5

    See identical proteins and their annotated locations for NP_079730.1

    Status: VALIDATED

    Source sequence(s)
    AK007536, AK028397, CAAA01224355
    Consensus CDS
    CCDS35673.1
    UniProtKB/Swiss-Prot
    Q3UL57, Q6P292, Q9CV64, Q9D8Y8, Q9D9V8
    Related
    ENSMUSP00000027505.7, ENSMUST00000027505.13
    Conserved Domains (2) summary
    cd15685
    Location:187 → 235
    PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
    pfam12998
    Location:6 → 105
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93731648..93749823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529792.4 → XP_006529855.1  inhibitor of growth protein 5 isoform X1

    Conserved Domains (2) summary
    cd15685
    Location:186 → 234
    PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
    cd16863
    Location:12 → 104
    ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029340.1: Suppressed sequence

    Description
    NM_029340.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8Y8.1 GenPept UniProtKB/Swiss-Prot:Q9D8Y8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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