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Tm4sf20 transmembrane 4 L six family member 20 [ Mus musculus (house mouse) ]

Gene ID: 66261, updated on 11-Apr-2024

Summary

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Official Symbol
Tm4sf20provided by MGI
Official Full Name
transmembrane 4 L six family member 20provided by MGI
Primary source
MGI:MGI:1913511
See related
Ensembl:ENSMUSG00000026149 AllianceGenome:MGI:1913511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810018L02Rik
Summary
Predicted to be involved in negative regulation of proteolysis. Predicted to be located in endoplasmic reticulum membrane; focal adhesion; and plasma membrane. Predicted to be integral component of membrane. Is expressed in alimentary system; central nervous system; lung; retina; and urethra. Human ortholog(s) of this gene implicated in specific language impairment. Orthologous to human TM4SF20 (transmembrane 4 L six family member 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 49.6), small intestine adult (RPKM 22.0) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C5; 1 42.48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (82734368..82746182, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (82756647..82768461, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 3 Neighboring gene RIKEN cDNA C430014B12 gene Neighboring gene STARR-seq mESC enhancer starr_01479 Neighboring gene mitochondrial fission factor Neighboring gene predicted gene, 19257 Neighboring gene predicted gene, 34286

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Anderson KR, et al. Development, 2011 Aug. PMID 21750032, Free PMC Article
  2. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
  3. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Clone Names

  • MGC143474

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane 4 L6 family member 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368252.1 → NP_001355181.1  transmembrane 4 L6 family member 20 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AK007532, AK017195, AK017209, AV378190, BE686508

  2. NM_025453.4 → NP_079729.1  transmembrane 4 L6 family member 20 isoform 1

    See identical proteins and their annotated locations for NP_079729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK007532, AK017195, AK017209, AV378190
    Consensus CDS
    CCDS15099.1
    UniProtKB/Swiss-Prot
    Q9CQY8, Q9D3Q0, Q9D3R0
    Related
    ENSMUSP00000027331.3, ENSMUST00000027331.3
    Conserved Domains (1) summary
    pfam05805
    Location:2 → 220
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    82734368..82746182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQY8.1 GenPept UniProtKB/Swiss-Prot:Q9CQY8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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