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Ssr2 signal sequence receptor, beta [ Mus musculus (house mouse) ]

Gene ID: 66256, updated on 5-Mar-2024

Summary

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Official Symbol
Ssr2provided by MGI
Official Full Name
signal sequence receptor, betaprovided by MGI
Primary source
MGI:MGI:1913506
See related
Ensembl:ENSMUSG00000041355 AllianceGenome:MGI:1913506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TLAP; TRAPB; SSR-beta; TRAPbeta; 1500032E05Rik
Summary
Acts upstream of or within in utero embryonic development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in cranium; genitourinary system; and pancreas epithelium. Orthologous to human SSR2 (signal sequence receptor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 192.7), large intestine adult (RPKM 147.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ssr2 in Genome Data Viewer
Location:
3 F1; 3 38.88 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88486915..88495727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88579608..88588420)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8803 Neighboring gene ubiquilin 4 Neighboring gene STARR-seq mESC enhancer starr_08200 Neighboring gene STARR-seq mESC enhancer starr_08201 Neighboring gene STARR-positive B cell enhancer ABC_E6069 Neighboring gene RNA transcription, translation and transport factor, pseudogene Neighboring gene STARR-seq mESC enhancer starr_08203 Neighboring gene STARR-seq mESC enhancer starr_08204 Neighboring gene STARR-positive B cell enhancer ABC_E9078 Neighboring gene STARR-positive B cell enhancer ABC_E6070 Neighboring gene predicted gene, 52660 Neighboring gene Rho/Rac guanine nucleotide exchange factor 2 Neighboring gene predicted gene, 40090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The concept of translocational regulation. Hegde RS, et al. J Cell Biol, 2008 Jul 28. PMID 18644895, Free PMC Article
  2. Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Radford BN, et al. Nat Commun, 2023 Mar 1. PMID 36859534, Free PMC Article
  3. High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis. Uematsu R, et al. Mol Cell Proteomics, 2005 Dec. PMID 16170054
  4. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, et al. Nature, 2021 Feb. PMID 33505018
  5. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
translocon-associated protein subunit beta
Names
signal sequence receptor subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356316.1 → NP_001343245.1  translocon-associated protein subunit beta isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS89648.1
    UniProtKB/TrEMBL
    A0A0A6YXB7
    Related
    ENSMUSP00000141922.2, ENSMUST00000192495.6
    Conserved Domains (1) summary
    pfam05753
    Location:15 → 181
    TRAP_beta; Translocon-associated protein beta (TRAPB)

  2. NM_001356317.1 → NP_001343246.1  translocon-associated protein subunit beta isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC145168, AK005340
    Consensus CDS
    CCDS17480.1
    UniProtKB/Swiss-Prot
    Q91Z43, Q9CPW5, Q9CR94, Q9CX54
    Related
    ENSMUSP00000141441.2, ENSMUST00000195014.6
    Conserved Domains (1) summary
    pfam05753
    Location:15 → 179
    TRAP_beta; Translocon-associated protein beta (TRAPB)

  3. NM_001356318.1 → NP_001343247.1  translocon-associated protein subunit beta isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Conserved Domains (1) summary
    pfam05753
    Location:15 → 177
    TRAP_beta; Translocon-associated protein beta (TRAPB)

  4. NM_001356319.1 → NP_001343248.1  translocon-associated protein subunit beta isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS89649.1
    UniProtKB/TrEMBL
    A0A0A6YVZ1
    Related
    ENSMUSP00000141325.2, ENSMUST00000193934.6
    Conserved Domains (1) summary
    pfam05753
    Location:15 → 160
    TRAP_beta; Translocon-associated protein beta (TRAPB)

  5. NM_025448.4 → NP_079724.1  translocon-associated protein subunit beta isoform 2 precursor

    See identical proteins and their annotated locations for NP_079724.1

    Status: VALIDATED

    Source sequence(s)
    AC145168, AK050505
    Consensus CDS
    CCDS17480.1
    UniProtKB/Swiss-Prot
    Q91Z43, Q9CPW5, Q9CR94, Q9CX54
    Related
    ENSMUSP00000045456.8, ENSMUST00000035785.9
    Conserved Domains (1) summary
    pfam05753
    Location:15 → 179
    TRAP_beta; Translocon-associated protein beta (TRAPB)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88486915..88495727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPW5.1 GenPept UniProtKB/Swiss-Prot:Q9CPW5

Gene LinkOut

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