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Hspbp1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 [ Mus musculus (house mouse) ]

Gene ID: 66245, updated on 9-May-2024

Summary

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Official Symbol
Hspbp1provided by MGI
Official Full Name
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1provided by MGI
Primary source
MGI:MGI:1913495
See related
Ensembl:ENSMUSG00000063802 AllianceGenome:MGI:1913495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500019G21Rik
Summary
Predicted to enable adenyl-nucleotide exchange factor activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Orthologous to human HSPBP1 (HSPA (Hsp70) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.7), adrenal adult (RPKM 23.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 2.69 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4663514..4688218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4660515..4685188, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 86B Neighboring gene protein phosphatase 6, regulatory subunit 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4605526-4605679 Neighboring gene STARR-positive B cell enhancer ABC_E3695 Neighboring gene STARR-positive B cell enhancer ABC_E2219 Neighboring gene BR serine/threonine kinase 1 Neighboring gene transmembrane protein 150B Neighboring gene predicted gene, 24537

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Rogon C, et al. Mol Biol Cell, 2014 Aug 1. PMID 24899640, Free PMC Article
  2. The Hsc/Hsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells. Kettern N, et al. PLoS One, 2011 Jan 20. PMID 21283720, Free PMC Article
  3. CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice. Zhang C, et al. Am J Physiol Heart Circ Physiol, 2005 Jun. PMID 15665051
  4. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Zhao T, et al. Proc Natl Acad Sci U S A, 2017 Sep 12. PMID 28847953, Free PMC Article
  5. A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability. Koochaki SHJ, et al. J Biol Chem, 2022 Oct. PMID 36108743, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male HSPBP1knockout mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes.
    Title: HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.
  2. Provides a critical cardioprotective effect in the setting of ischemia-reperfusion injury due in part to increased apoptosis in cardiac cells.
    Title: CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hsp70-binding protein 1
Names
SPA ) binding protein, cytoplasmic cochaperone 1
heat shock protein-binding protein 1
hsp70-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360629.1 → NP_001347558.1  hsp70-binding protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20740.1
    UniProtKB/Swiss-Prot
    Q99P31, Q9CYV8
    Conserved Domains (2) summary
    sd00043
    Location:135 → 172
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:43 → 137
    Fes1; Nucleotide exchange factor Fes1

  2. NM_024172.4 → NP_077134.1  hsp70-binding protein 1

    See identical proteins and their annotated locations for NP_077134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20740.1
    UniProtKB/Swiss-Prot
    Q99P31, Q9CYV8
    Related
    ENSMUSP00000078886.5, ENSMUST00000079970.6
    Conserved Domains (2) summary
    sd00043
    Location:135 → 172
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:43 → 137
    Fes1; Nucleotide exchange factor Fes1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4663514..4688218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242890.2 → XP_030098750.1  hsp70-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99P31, Q9CYV8
    Conserved Domains (2) summary
    sd00043
    Location:135 → 172
    ARM; armadillo repeat [structural motif]
    pfam08609
    Location:43 → 137
    Fes1; Nucleotide exchange factor Fes1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P31.1 GenPept UniProtKB/Swiss-Prot:Q99P31

Gene LinkOut

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