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Nemf nuclear export mediator factor [ Mus musculus (house mouse) ]

Gene ID: 66244, updated on 21-Apr-2024

Summary

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Official Symbol
Nemfprovided by MGI
Official Full Name
nuclear export mediator factorprovided by MGI
Primary source
MGI:MGI:1918305
See related
Ensembl:ENSMUSG00000020982 AllianceGenome:MGI:1918305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sdccag1; 1500011I12Rik; 4933405E14Rik
Summary
Predicted to enable ribosomal large subunit binding activity and tRNA binding activity. Predicted to be involved in nuclear export; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Part of RQC complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Used to study neuropathy. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 12.6), CNS E14 (RPKM 9.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 28.78 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69358315..69403975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69311541..69357201, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene STARR-positive B cell enhancer ABC_E10753 Neighboring gene kelch domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_32363 Neighboring gene kelch domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_32364 Neighboring gene STARR-positive B cell enhancer ABC_E10754 Neighboring gene STARR-positive B cell enhancer ABC_E7139 Neighboring gene STARR-positive B cell enhancer ABC_E600 Neighboring gene STARR-seq mESC enhancer starr_32366 Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival. Udagawa T, et al. Cell Rep, 2021 Jan 5. PMID 33406423
  2. NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease. Martin PB, et al. Nat Commun, 2020 Sep 15. PMID 32934225, Free PMC Article
  3. Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. Thrun A, et al. Mol Cell, 2021 May 20. PMID 33909987, Free PMC Article
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
    Title: NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-aminoacyl-tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CAT tailing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CAT tailing ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RQC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosome quality control complex subunit NEMF
Names
nuclear export mediator factor Nemf
serologically defined colon cancer antigen 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025441.3 → NP_079717.2  ribosome quality control complex subunit NEMF

    See identical proteins and their annotated locations for NP_079717.2

    Status: VALIDATED

    Source sequence(s)
    AK039497, AK149005, BC039647, BY241581, CB524482
    Consensus CDS
    CCDS25951.1
    UniProtKB/Swiss-Prot
    Q3TAS9, Q3UF46, Q66JX6, Q8C9R6, Q8CA65, Q8CCP0, Q8JZT9, Q8R072, Q9CW30, Q9CYB8, Q9D4A9
    Related
    ENSMUSP00000021368.9, ENSMUST00000021368.10
    Conserved Domains (4) summary
    COG1293
    Location:1 → 642
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:530 → 604
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:959 → 1055
    DUF3441; Domain of unknown function (DUF3441)
    cl22451
    Location:656 → 762
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69358315..69403975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246848.2 → XP_030102708.1  ribosome quality control complex subunit NEMF isoform X2

    Conserved Domains (2) summary
    pfam05670
    Location:175 → 285
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:611 → 702
    DUF3441; Domain of unknown function (DUF3441)

  2. XM_011244157.4 → XP_011242459.1  ribosome quality control complex subunit NEMF isoform X1

    Conserved Domains (1) summary
    COG1293
    Location:1 → 642
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181665.1: Suppressed sequence

    Description
    NM_181665.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCP0.2 GenPept UniProtKB/Swiss-Prot:Q8CCP0

Gene LinkOut

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